Overview of 2D-LC applications from 2011 until present

We are in the process of expanding the database backwards in time. Please use the contact button or special form to notify us of any mistakes or a method we might have missed.

Modulation: Passive modulation = empty loops, ASM = Active-solvent modulation, EM = Evaporation membrane, FSM = Fixed-solvent modulation, SPAM = Stationary-phase-assisted modulation, VEM = Vacuum-evaporation modulation.
Detection: CAD = charged-aerosol detection, ELSD = evaporative light-scattering detection, FLD = fluorescence detection, LS = light scattering, MS = mass spectrometry, RID = refractive-index detection, VI = viscometry. LS, RID, and VI are typically combined to obtain “triple detection”.



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Application Category Coupling Mode Modulation 1D 2D Detection Reference Year
Branched polystyrene Polymers on-line comprehensive Passive RP-TGIC LCCC UV-vis Im et al. 2006
Branched polystyrene Polymers on-line comprehensive Passive LCCC SEC UV-vis Im et al. 2006
PS-b-PMMA diblock copolymer Polymers on-line comprehensive Passive RPLC SEC UV-vis Lee et al. 2015
Therapeutic antibodies (Histidine degradation) Biopharma on-line comprehensive Passive SEC HILIC MS, UV-vis Wang et al. 2015
Metabolites (mushroom extracts) Food off-line heart-cut Manual RPLC RPLC UV-vis Pandohee et al. 2015
Antibody-drug conjugates Biopharma on-line heart-cut Passive SEC RPLC UV-vis Goyon et al. 2018
Antibody-drug conjugates Biopharma on-line heart-cut Passive RPLC RPLC UV-vis Venkatramani et al. 2017
Antibody-drug conjugates Biopharma on-line heart-cut Passive SEC RPLC UV-vis Li et al. 2016
Antibody-drug conjugates Biopharma on-line heart-cut Passive HIC RPLC MS Gilroy et al. 2017
Antibody-drug conjugates Biopharma on-line comprehensive Passive RPLC RPLC MS, UV-vis Sandra et al. 2016
Antibody-drug conjugates Biopharma on-line heart-cut Passive RPLC RPLC MS, UV-vis Sandra et al. 2016
Antibody-drug conjugates Biopharma on-line comprehensive Passive HIC RPLC MS, UV-vis Sarrut et al. 2016
Antibody-drug conjugates Biopharma on-line comprehensive Passive HIC SEC MS Ehkirch et al. 2018
Antibody-drug conjugates (free species) Biopharma on-line heart-cut Passive SEC RPLC UV-vis Li et al. 2016
Antibody-drug conjugates (free species) Biopharma on-line heart-cut Passive MM RPLC MS Birdsall et al. 2016
Biopharmaceuticals (impurities) Biopharma on-line mult. heart-cut Passive RPLC RPLC MS Petersson et al. 2016
Bovine insulin (degradants) Biopharma on-line heart-cut ASM RPLC RPLC UV-vis Stoll et al. 2017
Monoclonal antibodies Biopharma on-line heart-cut Passive Affinity SEC UV-vis Williams et al. 2017
Monoclonal antibodies Biopharma on-line heart-cut Passive WCX SEC UV-vis An et al. 2017
Monoclonal antibodies Biopharma on-line comprehensive Passive SCX RPLC MS Sorensen et al. 2016
Monoclonal antibodies Biopharma on-line heart-cut Passive SCX RPLC MS Gstöttner et al. 2018
Oligonucleotides (impurities) Biopharma on-line heart-cut SPAM SEC IP-RPLC MS Roussis et al. 2018
Oligonucleotides (impurities) Biopharma on-line comprehensive SPAM RPLC IP-RPLC MS Roussis et al. 2018
Oligonucleotides (impurities) Biopharma on-line heart-cut SPAM SAX IP-RPLC MS Roussis et al. 2018
Oligonucleotides (impurities) Biopharma on-line comprehensive SPAM IP-RPLC IP-RPLC MS Roussis et al. 2018
Therapeutic antibodies Biopharma on-line heart-cut Passive IEX RPLC MS Bathke et al. 2018
Therapeutic antibodies Biopharma on-line comprehensive ASM HILIC RPLC MS Stoll et al. 2018
Wastewater effluent (AChE inhib.) Environmental on-line comprehensive Passive RPLC RPLC MS, UV-vis Ouyang et al. 2016
Emerging contaminants Environmental on-line comprehensive Passive RPLC RPLC MS Leonhardt 2016
Polycyclic aromatics Environmental on-line comprehensive Passive RPLC RPLC UV-vis Graesbøll et al. 2017
Black chokeberries pomace Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Brazdauskas et al. 2016
Overripe fruits (carotenoids) Food on-line comprehensive Passive NPLC RPLC MS, UV-vis Cacciola et al. 2016
Hop cones, pellet extracts Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Sommella et al. 2018
Hop cones, pellet extracts Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Sommella et al. 2018
Soybean (Kunitz Trypsin Inhibitor) Food off-line heart-cut Manual WAX SEC MS Zhou et al. 2017
Corn oil (Triacylglycerols) Food on-line comprehensive Passive AgLC RPLC MS Navarro-Reig et al. 2016
Tea, Grape seed, red wine (extracts) Food on-line comprehensive Passive HILIC RPLC IMS-MS Venter et al. 2018
Wine (polyphenols and contaminants) Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Donato et al. 2016
Acyl-Coenzyme A (mouse liver) Metabolites on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Amino acids (of gramicidin, bacitracin) Metabolites on-line comprehensive Passive Chiral Chiral UV-vis Woiwode et al. 2018
Amino acids (tea, amino acids) Metabolites off-line heart-cut Manual RPLC Chiral UV-vis Wang et al. 2017
Antioxidants (Malus hupehensis) Metabolites off-line heart-cut Manual HILIC RPLC MS, UV-vis Liu et al. 2018
Breast milk (fluoxetine, norfluoxetine) Metabolites on-line heart-cut Passive SEC Chiral MS Lopes et al. 2018
Breast milk (fluoxetine, norfluoxetine) Metabolites on-line heart-cut Passive SEC RPLC MS Alvim-Jr. et al. 2016
Flavonoids Metabolites off-line heart-cut Manual HILIC RPLC MS Yao et al. 2017
Flavonoids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Corgier et al. 2016
Flavonoids from licorice Metabolites off-line heart-cut Manual NPLC RPLC MS, UV-vis Fan et al. 2016
Furanocoumarins Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Cook et al. 2017
Lipidomics (brain tissue) Metabolites on-line heart-cut SPAM HILIC RPLC MS Berkecz et al. 2018
Lipidomics (human plasma) Metabolites on-line heart-cut VEM NPLC RPLC MS Shen et al. 2017
Lipidomics (mice serum) Metabolites on-line heart-cut VEM NPLC RPLC MS Weng et al. 2016
Lipidomics (rat plasma) Metabolites off-line heart-cut Manual MM RPLC MS Narváez-Rivas et al. 2017
Lipidomics (cyanobacteria) Metabolites on-line heart-cut VEM NPLC RPLC MS Shan et al. 2016
Lipidomics (human plasma) Metabolites on-line comprehensive Passive RPLC HILIC MS Baglai et al. 2017
Lipids (rice) Metabolites on-line comprehensive Passive RPLC HILIC MS Navarro-Reig et al. 2018
Metabolites (Escherichia coli) Metabolites on-line comprehensive Passive RPLC RPLC MS, UV-vis Cacciola et al. 2018
Metabolites (green cocoa beans) Metabolites on-line comprehensive SPAM HILIC RPLC MS, UV-vis Toro-Uribe et al. 2018
Metabolites (licorice) Metabolites on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2016
Metabolites (microbial) Metabolites on-line comprehensive SPAM RPLC RPLC UV-vis Yan et al. 2016
Metabolites (Panax notoginseng leaves) Metabolites off-line comprehensive Manual HILIC RPLC MS, UV-vis Yao et al. 2018
Metabolites (rice plant) Metabolites on-line comprehensive Passive HILIC RPLC MS Navarro-Reig et al. 2017
Metabolites (Vitamin D, human serum) Metabolites on-line heart-cut SPAM RPLC RPLC MS Mena-Bravo et al. 2016
Metabolites and lipids (human plasma) Metabolites on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Metabolomics (Glycyrrhiza glabra) Metabolites on-line comprehensive Passive RPLC RPLC MS, UV-vis Wong et al. 2018
Phenolic acids Metabolites on-line comprehensive EMM RPLC RPLC UV-vis Fornells et al. 2018
Phenolic acids and flavonoids Metabolites on-line comprehensive Passive MM RPLC UV-vis Hájek et al. 2016
Phenolic compounds (Grapevine canes) Metabolites on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2018
Plant extracts and coffee Metabolites on-line heart-cut Passive RPLC RPLC MS Stephan et al. 2016
Polyphenols Metabolites on-line comprehensive SPAM HILIC RPLC MS Sommella et al. 2017
Polyphenols in red raspberry fruits shoots Metabolites on-line comprehensive Passive RPLC RPLC MS Kula et al. 2016
Procyanidins (cocoa) Metabolites on-line comprehensive Passive HILIC RPLC UV-vis Muller et al. 2018
Proteinogenic amino acids Metabolites on-line heart-cut Passive RPLC Chiral UV-vis Woiwode et al. 2018
Steroids Metabolites on-line comprehensive Passive TRLC RPLC UV-vis Baert et al. 2018
Testosterone (human serum) Metabolites on-line heart-cut Passive RPLC RPLC MS Vamethevan et al. 2016
Urine (bovine) Metabolites on-line comprehensive SPAM RPLC RPLC MS Baglai et al. 2018
Urine (Steroids, Sulphonamides) Metabolites on-line comprehensive Passive RPLC RPLC MS Blokland et al. 2018
Bioactives in plant extracts Miscellaneous on-line comprehensive SPAM RPLC RPLC ELSD Coulerie et al. 2016
Heavy-oil fractions Miscellaneous on-line comprehensive Passive NA-RPLC NA-RPLC CAD, UV-vis van Beek et al. 2018
Household dust and dryer lint Miscellaneous on-line comprehensive Passive RPLC RPLC MS Ouyang et al. 2017
Lignin phenols Miscellaneous on-line comprehensive SPAM RPLC SFC UV-vis Sun et al. 2018
Synthetic cannabinoids Miscellaneous on-line comprehensive Passive RPLC RPLC MS Eckberg et al. 2018
Synthetic dyes Miscellaneous on-line comprehensive Passive SAX IP-RPLC UV-vis Pirok et al. 2016
Tobacco Miscellaneous on-line heart-cut SPAM SCX RPLC MS Shao et al. 2017
Tobacco (snus) Miscellaneous on-line heart-cut Passive RPLC RPLC MS Gi et al. 2017
Vacuum-gas oil fraction Miscellaneous on-line comprehensive SPAM RPLC RPLC MS Jakobsen et al. 2017
Phlorotannins in brown algae Natural medicines on-line comprehensive Passive HILIC RPLC MS, UV-vis Sánchez-Camargo et al. 2016
Brown seaweed Natural medicines on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2016
TCM (Additives) Natural medicines on-line heart-cut SPAM Affinity RPLC UV-vis Guo et al. 2017
TCM (Dracocephalum heterophyllium) Natural medicines off-line heart-cut Manual RPLC HILIC MS, NMR Dang et al. 2018
TCM (U. rhynchophylla) Natural medicines off-line heart-cut Manual MM MM UV-vis Wei et al. 2016
TCM (Curcuma kwangsiensis) Natural medicines on-line comprehensive Passive RPLC RPLC MS Zhou et al. 2018
TCM (Flos Carthami, dried flowers) Natural medicines on-line comprehensive SPAM MM RPLC UV-vis Wang et al. 2017
TCM (Gardenia jasminoides Ellis) Natural medicines off-line comprehensive Manual RPLC HILIC MS Zhou et al. 2017
TCM (Gegen-Qinlian Decoction) Natural medicines on-line comprehensive Passive RPLC RPLC MS Qiao et al. 2016
TCM (Notoginseng total saponins) Natural medicines off-line comprehensive Manual HILIC RPLC MS Yang et al. 2016
TCM (Oxytropis falcata) Natural medicines off-line heart-cut Manual RPLC RPLC UV-vis Wang et al. 2017
TCM (Salvia miltiorrhiza) Natural medicines off-line comprehensive Manual HILIC RPLC MS Sun et al. 2016
TCM (Salvia miltiorrhiza) Natural medicines on-line comprehensive Passive RPLC RPLC MS Cao et al. 2016
TCM (sapinins and alkaloids) Natural medicines off-line heart-cut Manual RPLC RPLC MS Jin et al. 2018
TCM (saponins in Gleditsia sinensis) Natural medicines on-line comprehensive Passive RPLC RPLC MS Wang et al. 2016
TCM (Sphaerophysa salsula) Natural medicines off-line heart-cut Manual RPLC HILIC NMR,UV-vis Jiao et al. 2017
TCM (toad skin) Natural medicines off-line comprehensive Manual NPLC RPLC MS Zhang et al. 2016
TCM (Tropane alkaloids) Natural medicines on-line heart-cut Passive RPLC SCX UV-vis Long et al. 2018
TCM (Xuebijing) Natural medicines on-line heart-cut Passive RPLC RPLC MS, UV-vis Lin et al. 2018
TCM (Zhibai Dihuang Granule) Natural medicines off-line comprehensive Manual SCX RPLC MS Liu et al. 2018
TCM (Denzhan Shenmai) Natural medicines off-line comprehensive Passive RPLC RPLC MS Sheng et al. 2017
TCM (Denzhan Shenmai) Natural medicines on-line heart-cut Passive RPLC Chiral MS Sheng et al. 2017
TCM (Ginseng powder) Natural medicines on-line heart-cut Passive HILIC RPLC UV-vis Ji et al. 2016
TCM (Ginkgo biloba) Natural medicines off-line comprehensive Passive HILIC RPLC MS Ji et al. 2017
Peptide biomarkers (rat urine) Peptides off-line heart-cut Manual RPLC RPLC MS Zhang et al. 2018
Peptic digests Peptides on-line heart-cut SPAM RPLC MM MS Saleh et al. 2016
Peptides Peptides on-line comprehensive Passive RPLC RPLC MS, UV-vis Sarrut et al. 2017
Protein digests (plasma) Peptides off-line heart-cut Manual RPLC RPLC MS Yang et al. 2018
Tryptic peptides Peptides on-line heart-cut SPAM SCX RPLC MS Kwiatkowski et al. 2018
Tryptic peptides (Cortical neurons) Peptides on-line comprehensive SPAM SCX RPLC MS Chuang et al. 2018
Tryptic peptides (Elaeis Guineensis Jacq) Peptides on-line heart-cut SPAM RPLC RPLC MS Nascimento et al. 2018
Tryptic peptides (Flammulina velutipes) Peptides off-line heart-cut Manual RPLC RPLC MS Fang et al. 2017
Tryptic peptides (human tissue, cancer) Peptides on-line heart-cut Passive RPLC RPLC MS Lee et al. 2016
Tryptic peptides (mitochondrial proteins) Peptides off-line heart-cut Manual SCX RPLC MS Li et al. 2018
Tryptic peptides (lung adenocarcinoma) Peptides off-line heart-cut Manual SCX RPLC MS Li et al. 2018
Tryptic peptides (proteus mirabilis) Peptides off-line heart-cut Manual RPLC RPLC MS Dong et al. 2018
Tryptic peptides (Salmonella bacteria) Peptides off-line heart-cut Manual SCX RPLC MS Sun et al. 2018
Tryptic peptides (serum) Peptides off-line heart-cut Manual SCX RPLC MS Sun et al. 2017
Tryptic peptides (serum) Peptides off-line heart-cut Manual SCX RPLC MS Ye et al. 2017
Peptides Peptides on-line comprehensive Passive RPLC SEC UV-vis Xu et al. 2018
Peptides Peptides on-line heart-cut Passive Chiral RPLC FLD, MS Cheng et al. 2018
Peptides Peptides on-line heart-cut Passive Chiral Affinity FLD, MS Cheng et al. 2018
Peptides Peptides on-line comprehensive Passive SEC RPLC UV-vis Xu et al. 2017
Peptides Peptides on-line heart-cut Passive RPLC RPLC MS, UV-vis Luo et al. 2017
Antibiotic drug (cefonicid sodium) Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Antibiotic residues in dairy products Pharmaceuticals on-line heart-cut Passive HILIC RPLC MS Wang et al. 2017
Antibiotics Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Beta-blockers in human plasma Pharmaceuticals on-line heart-cut Passive SEC RPLC FLD Gonçalves et al. 2017
Desonide cream Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS Wang et al. 2018
Parental drug microdosing vehicle Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS, UV-vis Dai et al. 2017
Pharmaceutical materials Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS, UV-vis Yang et al. 2017
Pharmaceuticals Pharmaceuticals on-line selective compr. Passive RPLC SFC UV-vis Iguiniz et al. 2018
Pharmaceuticals Pharmaceuticals on-line comprehensive Passive Chiral Chiral UV-vis Barhate et al. 2017
Pharmaceuticals Pharmaceuticals on-line heart-cut Passive RPLC Chiral UV-vis Barhate et al. 2017
Pharmaceuticals Pharmaceuticals on-line heart-cut SPAM RPLC SFC MS, UV-vis Venkatramani et al. 2016
Pharmaceuticals Pharmaceuticals on-line comprehensive Passive RPLC RPLC MS, UV-vis Iguiniz et al. 2018
Pharmaceuticals, Metabolites Pharmaceuticals on-line heart-cut SPAM RPLC Chiral MS Goel et al. 2018
Therapeutic drug (in human plasma) Pharmaceuticals on-line heart-cut SPAM RPLC RPLC UV-vis Sheng et al. 2017
Vidarabine monophosphate Pharmaceuticals on-line heart-cut SPAM RPLC MM MS Wang et al. 2017
Vitamins Pharmaceuticals on-line heart-cut ASM HILIC RPLC UV-vis Bäurer et al. 2018
Oligomers (Oxidzed waxes) Polymers on-line comprehensive Passive NPLC SEC ELSD Ndiripo et al. 2018
Polyether polyols Polymers on-line comprehensive Passive HILIC RPLC MS Groeneveld et al. 2018
Polymeric nanoparticles Polymers on-line comprehensive SPAM HDC SEC UV-vis Pirok et al. 2017
Synthetic polymers (Polystyrene/ Polybutadiene Block Copolymers) Polymers on-line comprehensive SPAM NA-TGIC SEC UV-vis Lee et al. 2018
Synthetic polymers (Polystyrene/ Polybutadiene Block Copolymers) Polymers on-line comprehensive SPAM RP-TGIC LCCC UV-vis Lee et al. 2018
Synthetic polymers (novolac) Polymers on-line comprehensive ASM SEC RPLC UV-vis Pursch et al. 2018
Synthetic polymers (branched poly (bisphenol-A-carbonate)) Polymers on-line comprehensive Passive LCCC SEC LS, RID, UV-vis, VI Apel et al. 2018
Synthetic polymers (HEUR) Polymers on-line comprehensive Passive SEC RPLC ELSD Yang et al. 2018
Synthetic polymers (non-linear) Polymers on-line comprehensive Passive NPLC SEC LS, RID, VI Lee et al. 2016
Synthetic polymers (poloxamers) Polymers on-line comprehensive Passive LCCC LCCC ELSD Malik et al. 2016
Synthetic polymers (polystyrene) Polymers on-line comprehensive Passive NA-RPLC SEC UV-vis Urban et al. 2017
Intact histone proteoforms (Intact) Proteins on-line comprehensive SPAM MM RPLC MS Gargano et al. 2018
Intact proteins (Intact) Proteins on-line comprehensive Passive SCX RPLC UV-vis Lynch et al. 2018
Intact proteins and protein digests (Intact) Proteins on-line comprehensive Passive SCX IP-RPLC MS, UV-vis Vonk et al. 2015
Metaproteomics (soil) (Intact) Proteins on-line heart-cut SPAM SCX RPLC MS Callister et al. 2018
Proteins in human plasma (Intact) Proteins on-line comprehensive SPAM SAX RPLC None Huang et al. 2016
Ethoxylate phosphate surfactants Surfactants on-line comprehensive SPAM HILIC RPLC UV-vis Gargano et al. 2016
Ionic surfactants Surfactants on-line comprehensive Passive MM RPLC CAD Pirok et al. 2018
Non-ionic surfactants in pharmaceuticals Surfactants on-line comprehensive Passive HILIC RPLC ELSD, MS 2018
Polymeric dispersants in detergents Surfactants on-line heart-cut Passive SEC RPLC ELSD Yang et al. 2018
Pyrrolizidine alkaloids Metabolites on-line heart-cut Passive RPLC RPLC MS van de Schans et al. 2017
Lipidomics Metabolites on-line comprehensive Passive RPLC HILIC MS Holčapek et al. 2015
TCM Natural medicines off-line heart-cut Manual SCX RPLC MS Jiang et al. 2015
Fish oil (Triacylglycerol) Food on-line comprehensive Stop-flow AgLC NA-RPLC ELSD, MS Beccaria et al. 2015
Proteins from mouse adipose tissue (Intact) Proteins off-line comprehensive Manual SCX RPLC MS Sajic et al. 2015
Cannabinoids Natural medicines on-line heart-cut Passive RPLC RPLC MS, Other Pandohee et al. 2015
Dye extracts Miscellaneous on-line comprehensive SPAM SAX RPLC MS, UV-vis Pirok et al. 2019
Charged acrylic polymeric particles Polymers on-line comprehensive SPAM SEC SEC UV-vis Pirok et al. 2019
Pharmaceutical drugs Pharmaceuticals on-line comprehensive Passive RPLC RPLC MS, UV-vis Iguiniz et al. 2019
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC WAX MS Long et al. 2019
Phenolic compounds Metabolites on-line comprehensive Passive HILIC RPLC UV-vis Jandera et al. 2019
Natural phenolics in Rooibos tea, Grape seed Food on-line comprehensive FSM HILIC RPLC MS Muller et al. 2019
Panax ginseng root extract in saponin Traditional Chinese medicine on-line comprehensive Passive RPLC HILIC UV-vis Chen et al. 2019
Phenolic compounds in pomegranate Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Russo et al. 2019
Pistacia vera L. kernel extracts Food on-line comprehensive Passive RPLC RPLC MS Arena et al. 2019
Prebiotic oligosaccharides Food on-line comprehensive SPAM HILIC RPLC UV-vis Martín-Ortiz et al. 2019
Proteins in eggs Food on-line comprehensive SPAM SEC RPLC MS Melfi et al. 2019
Synthetic polymers (bimodal high-density polyethylene) Polymers on-line comprehensive Passive RPLC SEC ELSD Prabhu et al. 2015
TCM (ginsenosides in Panax ginseng) Natural medicines off-line comprehensive Manual HILIC RPLC MS Qiu et al. 2015
Lipidomics (mice serum) Metabolites on-line heart-cut VEM NPLC RPLC MS Weng et al. 2015
Monoclonal antibodies (rituximab) Biopharma on-line selective compr. Passive CEX RPLC MS Stoll et al. 2015
Benzophenones (transformation products) Environmental on-line mult. heart-cut Passive RPLC BMC Li et al. 2015
Natural polymers (carboxymethyl celluloses) Polymers on-line comprehensive Passive RPLC SEC ELSD Shakun et al. 2015
Metabolites (Pichia pastoris) Metabolites on-line heart-cut Passive RPLC RPLC MS Ortmayr et al. 2015
HBCD Isomersin PS Foam Polymers on-line mult. heart-cut Passive RPLC RPLC UV-vis Pursch et al. 2015
Peptides (Saccharomyces cerevisiae digest) Peptides on-line comprehensive SPAM SCX RPLC MS Vonk et al. 2015
Synthetic polymers (polystyrene block copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Wright et al. 2015
Metabolites Metabolites on-line comprehensive Passive RPLC RPLC MS Willmann et al. 2015
Aflatoxins (Aspergillus sp.) Food on-line heart-cut Passive RPLC RPLC MS Breidbach et al. 2015
Yoghurt (food additives) Food on-line heart-cut Stop-flow RPLC RPLC UV-vis Hou et al. 2015
Ramelteon (human serum) Pharmaceuticals on-line heart-cut Passive RPLC RPLC UV-vis Sagirli et al. 2015
Phospholipids Food on-line heart-cut Passive HILIC RPLC MS Sun et al. 2015
Phosphatidylcholine isomers Food on-line heart-cut Passive HILIC RPLC MS Sun et al. 2014
Therapeutic antibodies Biopharma on-line comprehensive Passive RPLC RPLC MS, UV-vis Vanhoenacker et al. 2015
Wastewater effluent (toxicants) Environmental on-line comprehensive Passive RPLC RPLC MS, UV-vis Ouyang et al. 2015
Peptides (from milk) Food on-line comprehensive Passive RPLC RPLC UV-vis Sommella et al. 2015
TCM (Tripterygium wilfordii Hook.f) Natural medicines on-line comprehensive Passive RPLC RPLC MS Qu et al. 2015
TCM (triterpenoid saponins) Natural medicines on-line heart-cut Stop-flow HILIC RPLC MS Wang et al. 2015
TCM (Carthamus tinctorius L.) Natural medicines off-line comprehensive Manual HILIC RPLC MS Yang et al. 2015
TCM (Panax notoginseng saponins) Natural medicines on-line mult. heart-cut Passive RPLC RPLC UV-vis Yao et al. 2015
Dairy products (Proteins and additives) Food on-line heart-cut Stop-flow RPLC RPLC UV-vis Hou et al. 2015
Flavonoids and iridoid glycosides in Hedyotis diffusa Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Li et al. 2015
Antibody-drug conjugates (free species) Biopharma on-line heart-cut Passive SEC RPLC MS, UV-vis Li et al. 2015
Pharmaceuticals (naproxen and degradants) Pharmaceuticals on-line comprehensive Passive RPLC RPLC UV-vis Stoll et al. 2015
Glycated albumin (digest) Peptides on-line heart-cut SPAM Affinity RPLC MS Pepaj et al. 2015
Tryptic digests Peptides on-line comprehensive Passive RPLC RPLC UV-vis Sarrut et al. 2015
Wastewater effluent (pharmaceuticals and pesticides) Environmental on-line comprehensive Passive RPLC RPLC MS Leonhardt et al. 2015
Carboxilic acids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Stoll et al. 2015
TCM (bufadienolides in toad skin) Natural medicines off-line comprehensive Manual NPLC RPLC MS Zhang et al. 2015
TCM (antioxidants in Ginkgo biloba extract) Natural medicines on-line comprehensive Passive RPLC RPLC UV-vis Guo et al. 2015
TCM (Hypericum ascyron extract) Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Li et al. 2015
Red chili pepper (caretenoids) Food on-line comprehensive Passive NPLC RPLC MS, UV-vis Mondello et al. 2014
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS, UV-vis Venkatramani et al. 2014
Vancomycin in plasma Pharmaceuticals on-line heart-cut SPAM RPLC RPLC UV-vis Li et al. 2014
Anthocyanins in blue berries, red radish, cabbage and black beans Food off-line comprehensive Passive HILIC RPLC MS Willemse et al. 2014
White wine and TCM Food on-line comprehensive Passive MM RPLC UV-vis Li et al. 2014
Neurotransmitters Metabolites on-line heart-cut Passive RPLC RPLC MS, Other Holland et al. 2014
Tryptic digest (endogenous PSA) Peptides on-line heart-cut SPAM HILIC RPLC MS Simon et al. 2014
Phosphatidylcholine isomers in cell membranes Miscellaneous on-line heart-cut Passive HILIC RPLC MS Sun et al. 2014
poly(styrene)-co-poly(methyl methacrylate)latex Polymers on-line comprehensive Passive RPLC SEC UV-vis Schoenmakers et al. 2014
Synthetic polymers (polystyrene) Polymers on-line comprehensive Passive NPLC SEC UV-vis Jeong et al. 2014
Synthetic polymers (polysorbate) Polymers on-line heart-cut Passive MM RPLC UV-vis Li et al. 2014
Bio-oil (organic acids) Miscellaneous on-line comprehensive Passive RPLC RPLC MS Le Masle et al. 2014
Oligonucleotides Miscellaneous off-line comprehensive Manual IP-RPLC CE UV-vis Porebski 2014
Milk powder (carbohydrates) Food on-line heart-cut SPAM RPLC RPLC RID Ma et al. 2014
Sugar phosphates in yeast cells Metabolites on-line heart-cut Passive SAX RPLC MS Klavins et al. 2014
Polycyclic aromatic compounds Miscellaneous on-line comprehensive Passive RPLC RPLC UV-vis Græsbøll et al. 2014
Corn seed, Gingo Biloba and valerian root Natural medicines on-line heart-cut SPAM RPLC RPLC UV-vis Allen et al. 2014
Polycyclic aromatic hydrocarbons Miscellaneous on-line comprehensive Passive RPLC RPLC UV-vis Place et al. 2014
Synthetic polymers (poly(propylene) copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Cheruthazhekatt et al. 2014
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC RPLC UV-vis Shackman et al. 2014
Phenolic antioxidants Food on-line comprehensive Passive HILIC RPLC Other, UV-vis Kalili et al. 2014
TCM (Radix et Rhizoma Asari) Natural medicines on-line heart-cut SPAM Affinity RPLC MS Han et al. 2014
Sugarcane leaf (polyphenols) Food on-line comprehensive Passive RPLC RPLC MS Leme et al. 2014
TCM (P. lobata) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Qiao et al. 2014
Lipidomics (human plasma) Metabolites on-line heart-cut VEM NPLC RPLC MS Li et al. 2014
Milk powder (flavonoids) Food on-line heart-cut SPAM RPLC RPLC UV-vis Ma et al. 2014
Fatty alcohol ethoxylates Surfactants on-line heart-cut Passive RPLC RPLC UV-vis Escrig-Doménech et al. 2014
Brown algae (phlorotannins) Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2014
Synthetic polymers (ethylene/1‐octene copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Mekab et al. 2014
Lipidomics (human plasma) Metabolites on-line comprehensive Stop-flow HILIC RPLC MS Wang et al. 2013
Furanocoumarins Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Tran et al. 2013
Red wine Food on-line comprehensive Passive MM RPLC UV-vis Matos et al. 2013
Wastewater effluent (contaminants) Environmental on-line comprehensive Passive RPLC RPLC MS Haun et al. 2013
Apples (phenolic compounds) Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2013
Synthetic polymers (tacticity of Poly(Methyl Methacrylates)) Polymers on-line comprehensive Passive RPLC SEC ELSD Maiko et al. 2013
Phospholipids Metabolites on-line heart-cut Passive SAX RPLC MS Bang et al. 2013
Grape Seed Food on-line comprehensive Passive HILIC RPLC MS Kalili et al. 2013
Pharmaceuticals (enantiomeric excess) Pharmaceuticals on-line heart-cut Passive NPLC Chiral UV-vis Liu et al. 2013
Tryptic digest (BSA, lysozyme and myoglobine) Peptides on-line comprehensive Passive RPLC RPLC UV-vis D'Attoma et al. 2013
Lipidomics Metabolites (porcine brain) off-line heart-cut Manual HILIC RPLC MS Cífková et al. 2013
Synthetic polymers (cellulose acetates) Polymers off-line heart-cut Manual NPLC SEC ELSD Ghareeb et al. 2013
Tartary buckwheat Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Ren et al. 2013
Synthetic polymers (high-density polyethylene) Polymers on-line comprehensive Passive RPLC SEC ELSD Ginzburg et al. 2013
TCM (Hedyotis diffusa) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Li et al. 2013
Lipidomics (human plasma) Metabolites on-line heart-cut VEM NPLC RPLC MS Li et al. 2013
Pesticide residues Food on-line heart-cut SPAM HILIC RPLC MS Kittlaus et al. 2013
Synthetic polymers (RAFT polymerization) Polymers on-line comprehensive Passive LCCC SEC ELSD Keddie et al. 2013
TCM (Amide alkaloids in Piper longumL.) Natural medicines off-line comprehensive Passive NPLC RPLC MS Li et al. 2013
Cocoa (procyanidins) Food on-line comprehensive Passive HILIC RPLC FLD, UV-vis 10.1016/j.chroma.2013.03.009 2013
Synthetic polymers (polypropylene copolymers) Polymers on-line comprehensive Passive NA-RPLC SEC ELSD Cheruthazhekatt et al. 2013
Synthetic polymers (functionalized polyolefins) Polymers on-line comprehensive Passive NA-RPLC SEC ELSD Ginzburg et al. 2013
Pesticides Food on-line heart-cut SPAM HILIC RPLC MS Kittlaus et al. 2013
Phospholipids Metabolites on-line comprehensive Stop-flow HILIC RPLC MS Dugo et al. 2013
Apiaceous vegetables (furanocoumarins) Food on-line selective compr. Passive RPLC RPLC UV-vis Larson et al. 2013
Tryptic digest (porcine circovirus type 2) Peptides off-line heart-cut Manual SCX RPLC MS Liu et al. 2013
Peanut oil (triacylglycerols) Food off-line comprehensive Manual NA-RPLC AgLC MS Hu et al. 2013
Tryptic digest (antiviral factors) Peptides off-line heart-cut Manual SCX RPLC MS Tong et al. 2013
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC Chiral UV-vis Lee et al. 2013
Fatty alcohol derivatives Surfactants on-line comprehensive Passive HILIC RPLC MS Elsner et al. 2012
Phenolic compounds Metabolites on-line comprehensive Passive HILIC RPLC UV-vis Jandera et al. 2012
Synthetic polymers (protonated and deuterated polystyrene) Polymers on-line comprehensive Passive LCCC SEC ELSD Sinha et al. 2012
Tryptic digest (Gly m 4 Protein) Peptides on-line heart-cut SPAM SAX RPLC MS, UV-vis Julka et al. 2012
Pharmaceutical drugs Pharmaceuticals off-line comprehensive Manual RPLC HILIC CAD, MS Schiesel 2012
Synthetic polymers (poly(ethylene oxide)) Polymers on-line comprehensive Passive RPLC SEC NMR Hiller et al. 2012
Histone post-translational modifications (Intact) Proteins off-line heart-cut Manual MM RPLC MS Tian et al. 2012
Tryptic digest (scorpion Buthus martensi Karsch venom) Peptides off-line heart-cut Manual RPLC HILIC MS Xu et al. 2012
Synthetic polymers (Poly(styrene‑b‑isoprene) Miktoarm StarCopolymers) Polymers on-line comprehensive Manual RPLC SEC ELSD, UV-vis Ljubič et al. 2012
Synthetic polymers (PMMA and polyurethanes) Polymers on-line comprehensive Passive RPLC SEC ELSD, UV-vis Uliyanchenko et al. 2012
Tryptic digest (host cell protein impurities) Peptides off-line heart-cut Manual RPLC RPLC MS Schenauer et al. 2012
Synthetic oligonucleotides Pharmaceuticals on-line comprehensive Passive HILIC RPLC MS Li et al. 2012
Maize seeds Food on-line comprehensive Passive RPLC RPLC UV-vis Allen et al. 2012
TCM (Anemarrhena asphodeloides, steroid glycoside) Natural medicines on-line comprehensive Passive RPLC RPLC MS Liu et al. 2012
Tryptic digest (Methylocellasilvestris) Peptides on-line heart-cut Passive RPLC RPLC MS Patel et al. 2012
TCM (Qingkailing) Natural medicines on-line selective compr. Passive RPLC RPLC MS, UV-vis Ma et al. 2012
Natural organic matter Environmental on-line comprehensive Passive HILIC SEC ELSD, FLD, UV-vis Duarte et al. 2012
Natural organic matter Environmental on-line comprehensive Passive RPLC SEC ELSD, FLD, UV-vis Duarte et al. 2012
Tryptic digest (Bacillus thuringiensis) Peptides on-line heart-cut SPAM SCX RPLC MS Huang et al. 2012
Natural antioxidants Metabolites off-line heart-cut Manual RPLC MEKC UV-vis Česla et al. 2012
TCM (Radix Angelica sinensis) Natural medicines on-line comprehensive Passive RPLC RPLC MS Dück et al. 2012
D‐/L‐phenylalanine Pharmaceuticals on-line heart-cut Passive RPLC Chiral UV-vis Venkatramani et al. 2012
D‐/L‐phenylalanine Pharmaceuticals on-line comprehensive Passive RPLC Chiral UV-vis Venkatramani et al. 2012
Organic acids (aromatics and flavanoids) Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Hájek et al. 2012
Shotgun proteomics Peptides on-line heart-cut SPAM HILIC RPLC MS Zhao et al. 2012
Rooibos tea (phenolics) Food on-line comprehensive Passive HILIC RPLC UV-vis Beelders et al. 2012
TCM (Stevia Rebaudiana) Natural medicines off-line comprehensive Manual RPLC HILIC MS Fu et al. 2012
Synthetic polymers (polystyrene-polyethylene oxide block copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Malik et al. 2012
TCM (Panax notoginseng saponins) Natural medicines off-line comprehensive Manual HILIC RPLC MS, UV-vis Xing et al. 2012
Peanut oil and mouse tissue (triacylglycerides) Lipids on-line heart-cut Passive AgLC RPLC MS Yang et al. 2012
Synthetic polymers (Branched Polymers) Polymers on-line comprehensive Passive RP-TGIC SEC LS, RI, VI Ahn et al. 2012
Synthetic polymers (Poly(styrene-block-t-butyl methacrylate) Copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Ljubič et al. 2012
Synthetic polymers (Poly(styrene-block-t-butyl methacrylate) Copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Ljubič et al. 2012
Tryptic digest (neutrophils) Peptides off-line heart-cut Manual SCX RPLC MS Trusch et al. 2012
Synthetic polymers (PDMS-PS block copolymers) Polymers off-line comprehensive Passive LCCC SEC ELSD, UV-vis Malik et al. 2012
Endocrine disrupting compounds in water Environmental on-line heart-cut Passive RPLC RPLC MS David Matějíček 2012
Corn seed Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Paek et al. 2012
Tryptic digest (rat brain) Peptides off-line heart-cut Manual RPLC WCX MS Cai et al. 2012
Maize seed extract Food on-line comprehensive Passive RPLC RPLC UV-vis Zhang et al. 2012
Wastewater effluent (cocaince) Environmental on-line selective compr. Passive RPLC RPLC MS Groskreutz et al. 2012
Opiates Pharmaceuticals on-line selective compr. Passive RPLC RPLC UV-vis Groskreutz et al. 2012
Taxanes Pharmaceuticals on-line heart-cut Passive HILIC RPLC MS Rezadoost et al. 2012
Licorice (liquiritin) Food off-line comprehensive Passive RPLC RPLC UV-vis Cong et al. 2012
Synthetic polymers (polypropylene Copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Cheruthazhekatt et al. 2012
Organic acids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Duarte et al. 2012
TCM (Scutellaria barbata D. Don) Natural medicines off-line comprehensive Manual HILIC RPLC MS, UV-vis Liang et al. 2012
TCM (Scutellaria barbata D. Don) Natural medicines off-line comprehensive Passive HILIC HILIC MS, UV-vis Liang et al. 2012
Tryptic digest (phosphorylated peptides) Peptides off-line heart-cut Manual RPLC RPLC MS Stephanowitz et al. 2012
Green and black tea (Camellia sinensis, phenolics) Food off-line comprehensive Manual SEC RPLC ELSD, UV-vis Scoparo et al. 2012
Tryptic digest (serum) Peptides off-line heart-cut Manual SCX RPLC MS Zhang et al. 2012
TCM (flavanoids) Natural medicines off-line heart-cut Manual RPLC RPLC MS Zeng et al. 2012
Monoclonal antibodies Biopharma on-line heart-cut SPAM RPLC RPLC MS Doneanu 2012
Alkylphenol polyethoxylates Surfactants on-line comprehensive Passive HILIC RPLC MS Wu et al. 2011
Monoclonal antibodies Biopharma on-line heart-cut SPAM MM RPLC MS, UV-vis Alvarez et al. 2011
Maize extract Food on-line comprehensive Passive RPLC RPLC UV-vis Filgueira et al. 2011
Synthetic polymers (poly(2-ethyl-2-oxazoline) copolymers) Polymers on-line comprehensive Passive LCCC SEC Baumgaertel et al. 2011
TCM Natural medicines off-line heart-cut SPAM RPLC HILIC UV-vis Cao et al. 2011
Synthetic polymers (poly(ethylene-co-propylene)) Polymers on-line comprehensive Passive RPLC SEC IR, LS, RI Lee et al. 2011
Synthetic polymers (polystyrene) Polymers off-line comprehensive Manual SEC HDC UV-vis Uliyanchenko et al. 2011
Maize extract Food on-line comprehensive Passive RPLC RPLC UV-vis Gu et al. 2011
Hydroxypropylmethylcellulose (HPMC) Polymers on-line comprehensive Passive RPLC SEC CAD Greuderer et al. 2011
Lipidomics (egg, soya, porcine brain) Metabolites off-line heart-cut Manual HILIC NA-RPLC MS Lísa et al. 2011
Myoglobin, serum albumin, pepstatin, proteinase inhibitor (Intact) Proteins on-line heart-cut SPAM SCX RPLC MS, UV-vis Julka et al. 2011
River water (pollutants in Monjolinho River) Environmental on-line heart-cut Passive Affinity Chiral MS Barreiro et al. 2011
Tryptic digest (Trypsin, bovine serum, ovalbumin, lysozyme, hemoglobin) Peptides on-line heart-cut Passive WAX RPLC UV-vis Li et al. 2011
Estrogens in sediments Environmental on-line heart-cut Passive RPLC RPLC MS DavidMatějíček 2011
Synthetic polymers (polyolefins) Polymers on-line comprehensive Passive RPLC SEC ELSD Ginzburg et al. 2011
Borago officinalis oil (triacylglycerols) Lipids on-line comprehensive Passive AgLC NA-RPLC ELSD Mondello et al. 2011
Flavones in Citrus juices Food on-line comprehensive Passive RPLC RPLC UV-vis Russo et al. 2011
Peptides Peptides on-line heart-cut Passive RPLC CE MS Chambers et al. 2011
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