Overview of 2D-LC applications from 1978 until present

Modulation: Passive modulation = empty loops, ASM = Active-solvent modulation, EM = Evaporation membrane, FSM = Fixed-solvent modulation, SPAM = Stationary-phase-assisted modulation, VEM = Vacuum-evaporation modulation.
Detection: CAD = charged-aerosol detection, ELSD = evaporative light-scattering detection, FLD = fluorescence detection, LS = light scattering, MS = mass spectrometry, RID = refractive-index detection, VI = viscometry. LS, RID, and VI are typically combined to obtain “triple detection”.



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Application Category Coupling Mode Modulation 1D 2D Detection Reference Year
Branched polystyrene Polymers on-line comprehensive Passive RP-TGIC LCCC UV-vis Im et al. 2006
Branched polystyrene Polymers on-line comprehensive Passive LCCC SEC UV-vis Im et al. 2006
PS-b-PMMA diblock copolymer Polymers on-line comprehensive Passive RPLC SEC UV-vis Lee et al. 2015
Therapeutic antibodies (Histidine degradation) Biopharma on-line comprehensive Passive SEC HILIC MS, UV-vis Wang et al. 2015
Metabolites (mushroom extracts) Food off-line heart-cut Manual RPLC RPLC UV-vis Pandohee et al. 2015
Antibody-drug conjugates Biopharma on-line heart-cut Passive SEC RPLC UV-vis Goyon et al. 2018
Antibody-drug conjugates Biopharma on-line heart-cut Passive RPLC RPLC UV-vis Venkatramani et al. 2017
Antibody-drug conjugates Biopharma on-line heart-cut Passive SEC RPLC UV-vis Li et al. 2016
Antibody-drug conjugates Biopharma on-line heart-cut Passive HIC RPLC MS Gilroy et al. 2017
Antibody-drug conjugates Biopharma on-line comprehensive Passive RPLC RPLC MS, UV-vis Sandra et al. 2016
Antibody-drug conjugates Biopharma on-line heart-cut Passive RPLC RPLC MS, UV-vis Sandra et al. 2016
Antibody-drug conjugates Biopharma on-line comprehensive Passive HIC RPLC MS, UV-vis Sarrut et al. 2016
Antibody-drug conjugates Biopharma on-line comprehensive Passive HIC SEC MS Ehkirch et al. 2018
Antibody-drug conjugates (free species) Biopharma on-line heart-cut Passive SEC RPLC UV-vis Li et al. 2016
Antibody-drug conjugates (free species) Biopharma on-line heart-cut Passive MM RPLC MS Birdsall et al. 2016
Biopharmaceuticals (impurities) Biopharma on-line mult. heart-cut Passive RPLC RPLC MS Petersson et al. 2016
Bovine insulin (degradants) Biopharma on-line heart-cut ASM RPLC RPLC UV-vis Stoll et al. 2017
Monoclonal antibodies Biopharma on-line heart-cut Passive Affinity SEC UV-vis Williams et al. 2017
Monoclonal antibodies Biopharma on-line heart-cut Passive WCX SEC UV-vis An et al. 2017
Monoclonal antibodies Biopharma on-line comprehensive Passive SCX RPLC MS Sorensen et al. 2016
Monoclonal antibodies Biopharma on-line heart-cut Passive SCX RPLC MS Gstöttner et al. 2018
Oligonucleotides (impurities) Biopharma on-line heart-cut SPAM SEC IP-RPLC MS Roussis et al. 2018
Oligonucleotides (impurities) Biopharma on-line comprehensive SPAM RPLC IP-RPLC MS Roussis et al. 2018
Oligonucleotides (impurities) Biopharma on-line heart-cut SPAM SAX IP-RPLC MS Roussis et al. 2018
Oligonucleotides (impurities) Biopharma on-line comprehensive SPAM IP-RPLC IP-RPLC MS Roussis et al. 2018
Therapeutic antibodies Biopharma on-line heart-cut Passive IEX RPLC MS Bathke et al. 2018
Therapeutic antibodies Biopharma on-line comprehensive ASM HILIC RPLC MS Stoll et al. 2018
Wastewater effluent (AChE inhib.) Environmental on-line comprehensive Passive RPLC RPLC MS, UV-vis Ouyang et al. 2016
Emerging contaminants Environmental on-line comprehensive Passive RPLC RPLC MS Leonhardt 2016
Polycyclic aromatics Environmental on-line comprehensive Passive RPLC RPLC UV-vis Graesbøll et al. 2017
Black chokeberries pomace Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Brazdauskas et al. 2016
Overripe fruits (carotenoids) Food on-line comprehensive Passive NPLC RPLC MS, UV-vis Cacciola et al. 2016
Hop cones, pellet extracts Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Sommella et al. 2018
Hop cones, pellet extracts Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Sommella et al. 2018
Soybean (Kunitz Trypsin Inhibitor) Food off-line heart-cut Manual WAX SEC MS Zhou et al. 2017
Corn oil (Triacylglycerols) Food on-line comprehensive Passive AgLC RPLC MS Navarro-Reig et al. 2016
Tea, Grape seed, red wine (extracts) Food on-line comprehensive Passive HILIC RPLC IMS-MS Venter et al. 2018
Wine (polyphenols and contaminants) Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Donato et al. 2016
Acyl-Coenzyme A (mouse liver) Metabolites on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Amino acids (of gramicidin, bacitracin) Metabolites on-line comprehensive Passive Chiral Chiral UV-vis Woiwode et al. 2018
Amino acids (tea, amino acids) Metabolites off-line heart-cut Manual RPLC Chiral UV-vis Wang et al. 2017
Antioxidants (Malus hupehensis) Metabolites off-line heart-cut Manual HILIC RPLC MS, UV-vis Liu et al. 2018
Breast milk (fluoxetine, norfluoxetine) Metabolites on-line heart-cut Passive SEC Chiral MS Lopes et al. 2018
Breast milk (fluoxetine, norfluoxetine) Metabolites on-line heart-cut Passive SEC RPLC MS Alvim-Jr. et al. 2016
Flavonoids Metabolites off-line heart-cut Manual HILIC RPLC MS Yao et al. 2017
Flavonoids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Corgier et al. 2016
Flavonoids from licorice Metabolites off-line heart-cut Manual NPLC RPLC MS, UV-vis Fan et al. 2016
Furanocoumarins Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Cook et al. 2017
Lipidomics (brain tissue) Metabolites on-line heart-cut SPAM HILIC RPLC MS Berkecz et al. 2018
Lipidomics (human plasma) Metabolites on-line heart-cut VEM NPLC RPLC MS Shen et al. 2017
Lipidomics (mice serum) Metabolites on-line heart-cut VEM NPLC RPLC MS Weng et al. 2016
Lipidomics (rat plasma) Metabolites off-line heart-cut Manual MM RPLC MS Narváez-Rivas et al. 2017
Lipidomics (cyanobacteria) Metabolites on-line heart-cut VEM NPLC RPLC MS Shan et al. 2016
Lipidomics (human plasma) Metabolites on-line comprehensive Passive RPLC HILIC MS Baglai et al. 2017
Lipids (rice) Metabolites on-line comprehensive Passive RPLC HILIC MS Navarro-Reig et al. 2018
Metabolites (Escherichia coli) Metabolites on-line comprehensive Passive RPLC RPLC MS, UV-vis Cacciola et al. 2018
Metabolites (green cocoa beans) Metabolites on-line comprehensive SPAM HILIC RPLC MS, UV-vis Toro-Uribe et al. 2018
Metabolites (licorice) Metabolites on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2016
Metabolites (microbial) Metabolites on-line comprehensive SPAM RPLC RPLC UV-vis Yan et al. 2016
Metabolites (Panax notoginseng leaves) Metabolites off-line comprehensive Manual HILIC RPLC MS, UV-vis Yao et al. 2018
Metabolites (rice plant) Metabolites on-line comprehensive Passive HILIC RPLC MS Navarro-Reig et al. 2017
Metabolites (Vitamin D, human serum) Metabolites on-line heart-cut SPAM RPLC RPLC MS Mena-Bravo et al. 2016
Metabolites and lipids (human plasma) Metabolites on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Metabolomics (Glycyrrhiza glabra) Metabolites on-line comprehensive Passive RPLC RPLC MS, UV-vis Wong et al. 2018
Phenolic acids Metabolites on-line comprehensive EMM RPLC RPLC UV-vis Fornells et al. 2018
Phenolic acids and flavonoids Metabolites on-line comprehensive Passive MM RPLC UV-vis Hájek et al. 2016
Phenolic compounds (Grapevine canes) Metabolites on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2018
Plant extracts and coffee Metabolites on-line heart-cut Passive RPLC RPLC MS Stephan et al. 2016
Polyphenols Metabolites on-line comprehensive SPAM HILIC RPLC MS Sommella et al. 2017
Polyphenols in red raspberry fruits shoots Metabolites on-line comprehensive Passive RPLC RPLC MS Kula et al. 2016
Procyanidins (cocoa) Metabolites on-line comprehensive Passive HILIC RPLC UV-vis Muller et al. 2018
Proteinogenic amino acids Metabolites on-line heart-cut Passive RPLC Chiral UV-vis Woiwode et al. 2018
Steroids Metabolites on-line comprehensive Passive TRLC RPLC UV-vis Baert et al. 2018
Testosterone (human serum) Metabolites on-line heart-cut Passive RPLC RPLC MS Vamethevan et al. 2016
Urine (bovine) Metabolites on-line comprehensive SPAM RPLC RPLC MS Baglai et al. 2018
Urine (Steroids, Sulphonamides) Metabolites on-line comprehensive Passive RPLC RPLC MS Blokland et al. 2018
Bioactives in plant extracts Miscellaneous on-line comprehensive SPAM RPLC RPLC ELSD Coulerie et al. 2016
Heavy-oil fractions Miscellaneous on-line comprehensive Passive NA-RPLC NA-RPLC CAD, UV-vis van Beek et al. 2018
Household dust and dryer lint Miscellaneous on-line comprehensive Passive RPLC RPLC MS Ouyang et al. 2017
Lignin phenols Miscellaneous on-line comprehensive SPAM RPLC SFC UV-vis Sun et al. 2018
Synthetic cannabinoids Miscellaneous on-line comprehensive Passive RPLC RPLC MS Eckberg et al. 2018
Synthetic dyes Miscellaneous on-line comprehensive Passive SAX IP-RPLC UV-vis Pirok et al. 2016
Tobacco Miscellaneous on-line heart-cut SPAM SCX RPLC MS Shao et al. 2017
Tobacco (snus) Miscellaneous on-line heart-cut Passive RPLC RPLC MS Gi et al. 2017
Vacuum-gas oil fraction Miscellaneous on-line comprehensive SPAM RPLC RPLC MS Jakobsen et al. 2017
Phlorotannins in brown algae Natural medicines on-line comprehensive Passive HILIC RPLC MS, UV-vis Sánchez-Camargo et al. 2016
Brown seaweed Natural medicines on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2016
TCM (Additives) Natural medicines on-line heart-cut SPAM Affinity RPLC UV-vis Guo et al. 2017
TCM (Dracocephalum heterophyllium) Natural medicines off-line heart-cut Manual RPLC HILIC MS, NMR Dang et al. 2018
TCM (U. rhynchophylla) Natural medicines off-line heart-cut Manual MM MM UV-vis Wei et al. 2016
TCM (Curcuma kwangsiensis) Natural medicines on-line comprehensive Passive RPLC RPLC MS Zhou et al. 2018
TCM (Flos Carthami, dried flowers) Natural medicines on-line comprehensive SPAM MM RPLC UV-vis Wang et al. 2017
TCM (Gardenia jasminoides Ellis) Natural medicines off-line comprehensive Manual RPLC HILIC MS Zhou et al. 2017
TCM (Gegen-Qinlian Decoction) Natural medicines on-line comprehensive Passive RPLC RPLC MS Qiao et al. 2016
TCM (Notoginseng total saponins) Natural medicines off-line comprehensive Manual HILIC RPLC MS Yang et al. 2016
TCM (Oxytropis falcata) Natural medicines off-line heart-cut Manual RPLC RPLC UV-vis Wang et al. 2017
TCM (Salvia miltiorrhiza) Natural medicines off-line comprehensive Manual HILIC RPLC MS Sun et al. 2016
TCM (Salvia miltiorrhiza) Natural medicines on-line comprehensive Passive RPLC RPLC MS Cao et al. 2016
TCM (sapinins and alkaloids) Natural medicines off-line heart-cut Manual RPLC RPLC MS Jin et al. 2018
TCM (saponins in Gleditsia sinensis) Natural medicines on-line comprehensive Passive RPLC RPLC MS Wang et al. 2016
TCM (Sphaerophysa salsula) Natural medicines off-line heart-cut Manual RPLC HILIC NMR,UV-vis Jiao et al. 2017
TCM (toad skin) Natural medicines off-line comprehensive Manual NPLC RPLC MS Zhang et al. 2016
TCM (Tropane alkaloids) Natural medicines on-line heart-cut Passive RPLC SCX UV-vis Long et al. 2018
TCM (Xuebijing) Natural medicines on-line heart-cut Passive RPLC RPLC MS, UV-vis Lin et al. 2018
TCM (Zhibai Dihuang Granule) Natural medicines off-line comprehensive Manual SCX RPLC MS Liu et al. 2018
TCM (Denzhan Shenmai) Natural medicines off-line comprehensive Passive RPLC RPLC MS Sheng et al. 2017
TCM (Denzhan Shenmai) Natural medicines on-line heart-cut Passive RPLC Chiral MS Sheng et al. 2017
TCM (Ginseng powder) Natural medicines on-line heart-cut Passive HILIC RPLC UV-vis Ji et al. 2016
TCM (Ginkgo biloba) Natural medicines off-line comprehensive Passive HILIC RPLC MS Ji et al. 2017
Peptide biomarkers (rat urine) Peptides off-line heart-cut Manual RPLC RPLC MS Zhang et al. 2018
Peptic digests Peptides on-line heart-cut SPAM RPLC MM MS Saleh et al. 2016
Peptides Peptides on-line comprehensive Passive RPLC RPLC MS, UV-vis Sarrut et al. 2017
Protein digests (plasma) Peptides off-line heart-cut Manual RPLC RPLC MS Yang et al. 2018
Tryptic peptides Peptides on-line heart-cut SPAM SCX RPLC MS Kwiatkowski et al. 2018
Tryptic peptides (Cortical neurons) Peptides on-line comprehensive SPAM SCX RPLC MS Chuang et al. 2018
Tryptic peptides (Elaeis Guineensis Jacq) Peptides on-line heart-cut SPAM RPLC RPLC MS Nascimento et al. 2018
Tryptic peptides (Flammulina velutipes) Peptides off-line heart-cut Manual RPLC RPLC MS Fang et al. 2017
Tryptic peptides (human tissue, cancer) Peptides on-line heart-cut Passive RPLC RPLC MS Lee et al. 2016
Tryptic peptides (mitochondrial proteins) Peptides off-line heart-cut Manual SCX RPLC MS Li et al. 2018
Tryptic peptides (lung adenocarcinoma) Peptides off-line heart-cut Manual SCX RPLC MS Li et al. 2018
Tryptic peptides (proteus mirabilis) Peptides off-line heart-cut Manual RPLC RPLC MS Dong et al. 2018
Tryptic peptides (Salmonella bacteria) Peptides off-line heart-cut Manual SCX RPLC MS Sun et al. 2018
Tryptic peptides (serum) Peptides off-line heart-cut Manual SCX RPLC MS Sun et al. 2017
Tryptic peptides (serum) Peptides off-line heart-cut Manual SCX RPLC MS Ye et al. 2017
Peptides Peptides on-line comprehensive Passive RPLC SEC UV-vis Xu et al. 2018
Peptides Peptides on-line heart-cut Passive Chiral RPLC FLD, MS Cheng et al. 2018
Peptides Peptides on-line heart-cut Passive Chiral Affinity FLD, MS Cheng et al. 2018
Peptides Peptides on-line comprehensive Passive SEC RPLC UV-vis Xu et al. 2017
Peptides Peptides on-line heart-cut Passive RPLC RPLC MS, UV-vis Luo et al. 2017
Antibiotic drug (cefonicid sodium) Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Antibiotic residues in dairy products Pharmaceuticals on-line heart-cut Passive HILIC RPLC MS Wang et al. 2017
Antibiotics Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS Wang et al. 2017
Beta-blockers in human plasma Pharmaceuticals on-line heart-cut Passive SEC RPLC FLD Gonçalves et al. 2017
Desonide cream Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS Wang et al. 2018
Parental drug microdosing vehicle Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS, UV-vis Dai et al. 2017
Pharmaceutical materials Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS, UV-vis Yang et al. 2017
Pharmaceuticals Pharmaceuticals on-line selective compr. Passive RPLC SFC UV-vis Iguiniz et al. 2018
Pharmaceuticals Pharmaceuticals on-line comprehensive Passive Chiral Chiral UV-vis Barhate et al. 2017
Pharmaceuticals Pharmaceuticals on-line heart-cut Passive RPLC Chiral UV-vis Barhate et al. 2017
Pharmaceuticals Pharmaceuticals on-line heart-cut SPAM RPLC SFC MS, UV-vis Venkatramani et al. 2016
Pharmaceuticals Pharmaceuticals on-line comprehensive Passive RPLC RPLC MS, UV-vis Iguiniz et al. 2018
Pharmaceuticals, Metabolites Pharmaceuticals on-line heart-cut SPAM RPLC Chiral MS Goel et al. 2018
Therapeutic drug (in human plasma) Pharmaceuticals on-line heart-cut SPAM RPLC RPLC UV-vis Sheng et al. 2017
Vidarabine monophosphate Pharmaceuticals on-line heart-cut SPAM RPLC MM MS Wang et al. 2017
Vitamins Pharmaceuticals on-line heart-cut ASM HILIC RPLC UV-vis Bäurer et al. 2018
Oligomers (Oxidzed waxes) Polymers on-line comprehensive Passive NPLC SEC ELSD Ndiripo et al. 2018
Polyether polyols Polymers on-line comprehensive Passive HILIC RPLC MS Groeneveld et al. 2018
Polymeric nanoparticles Polymers on-line comprehensive SPAM HDC SEC UV-vis Pirok et al. 2017
Synthetic polymers (Polystyrene/ Polybutadiene Block Copolymers) Polymers on-line comprehensive SPAM NA-TGIC SEC UV-vis Lee et al. 2018
Synthetic polymers (Polystyrene/ Polybutadiene Block Copolymers) Polymers on-line comprehensive SPAM RP-TGIC LCCC UV-vis Lee et al. 2018
Synthetic polymers (novolac) Polymers on-line comprehensive ASM SEC RPLC UV-vis Pursch et al. 2018
Synthetic polymers (branched poly (bisphenol-A-carbonate)) Polymers on-line comprehensive Passive LCCC SEC LS, RID, UV-vis, VI Apel et al. 2018
Synthetic polymers (HEUR) Polymers on-line comprehensive Passive SEC RPLC ELSD Yang et al. 2018
Synthetic polymers (non-linear) Polymers on-line comprehensive Passive NPLC SEC LS, RID, VI Lee et al. 2016
Synthetic polymers (poloxamers) Polymers on-line comprehensive Passive LCCC LCCC ELSD Malik et al. 2016
Synthetic polymers (polystyrene) Polymers on-line comprehensive Passive NA-RPLC SEC UV-vis Urban et al. 2017
Intact histone proteoforms (Intact) Proteins on-line comprehensive SPAM MM RPLC MS Gargano et al. 2018
Intact proteins (Intact) Proteins on-line comprehensive Passive SCX RPLC UV-vis Lynch et al. 2018
Intact proteins and protein digests (Intact) Proteins on-line comprehensive Passive SCX IP-RPLC MS, UV-vis Vonk et al. 2015
Metaproteomics (soil) (Intact) Proteins on-line heart-cut SPAM SCX RPLC MS Callister et al. 2018
Proteins in human plasma (Intact) Proteins on-line comprehensive SPAM SAX RPLC None Huang et al. 2016
Ethoxylate phosphate surfactants Surfactants on-line comprehensive SPAM HILIC RPLC UV-vis Gargano et al. 2016
Ionic surfactants Surfactants on-line comprehensive Passive MM RPLC CAD Pirok et al. 2018
Non-ionic surfactants in pharmaceuticals Surfactants on-line comprehensive Passive HILIC RPLC ELSD, MS 2018
Polymeric dispersants in detergents Surfactants on-line heart-cut Passive SEC RPLC ELSD Yang et al. 2018
Pyrrolizidine alkaloids Metabolites on-line heart-cut Passive RPLC RPLC MS van de Schans et al. 2017
Lipidomics Metabolites on-line comprehensive Passive RPLC HILIC MS Holčapek et al. 2015
TCM Natural medicines off-line heart-cut Manual SCX RPLC MS Jiang et al. 2015
Fish oil (Triacylglycerol) Food on-line comprehensive Stop-flow AgLC NA-RPLC ELSD, MS Beccaria et al. 2015
Proteins from mouse adipose tissue (Intact) Proteins off-line comprehensive Manual SCX RPLC MS Sajic et al. 2015
Cannabinoids Natural medicines on-line heart-cut Passive RPLC RPLC MS, Other Pandohee et al. 2015
Dye extracts Miscellaneous on-line comprehensive SPAM SAX RPLC MS, UV-vis Pirok et al. 2019
Charged acrylic polymeric particles Polymers on-line comprehensive SPAM SEC SEC UV-vis Pirok et al. 2019
Pharmaceutical drugs Pharmaceuticals on-line comprehensive Passive RPLC RPLC MS, UV-vis Iguiniz et al. 2019
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC WAX MS Long et al. 2019
Phenolic compounds Metabolites on-line comprehensive Passive HILIC RPLC UV-vis Jandera et al. 2019
Natural phenolics in Rooibos tea, Grape seed Food on-line comprehensive FSM HILIC RPLC MS Muller et al. 2019
Panax ginseng root extract in saponin Traditional Chinese medicine on-line comprehensive Passive RPLC HILIC UV-vis Chen et al. 2019
Phenolic compounds in pomegranate Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Russo et al. 2019
Pistacia vera L. kernel extracts Food on-line comprehensive Passive RPLC RPLC MS Arena et al. 2019
Prebiotic oligosaccharides Food on-line comprehensive SPAM HILIC RPLC UV-vis Martín-Ortiz et al. 2019
Proteins in eggs Food on-line comprehensive SPAM SEC RPLC MS Melfi et al. 2019
Synthetic polymers (bimodal high-density polyethylene) Polymers on-line comprehensive Passive RPLC SEC ELSD Prabhu et al. 2015
TCM (ginsenosides in Panax ginseng) Natural medicines off-line comprehensive Manual HILIC RPLC MS Qiu et al. 2015
Lipidomics (mice serum) Metabolites on-line heart-cut VEM NPLC RPLC MS Weng et al. 2015
Monoclonal antibodies (rituximab) Biopharma on-line selective compr. Passive CEX RPLC MS Stoll et al. 2015
Benzophenones (transformation products) Environmental on-line mult. heart-cut Passive RPLC BMC Li et al. 2015
Natural polymers (carboxymethyl celluloses) Polymers on-line comprehensive Passive RPLC SEC ELSD Shakun et al. 2015
Metabolites (Pichia pastoris) Metabolites on-line heart-cut Passive RPLC RPLC MS Ortmayr et al. 2015
HBCD Isomersin PS Foam Polymers on-line mult. heart-cut Passive RPLC RPLC UV-vis Pursch et al. 2015
Peptides (Saccharomyces cerevisiae digest) Peptides on-line comprehensive SPAM SCX RPLC MS Vonk et al. 2015
Synthetic polymers (polystyrene block copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Wright et al. 2015
Metabolites Metabolites on-line comprehensive Passive RPLC RPLC MS Willmann et al. 2015
Aflatoxins (Aspergillus sp.) Food on-line heart-cut Passive RPLC RPLC MS Breidbach et al. 2015
Yoghurt (food additives) Food on-line heart-cut Stop-flow RPLC RPLC UV-vis Hou et al. 2015
Ramelteon (human serum) Pharmaceuticals on-line heart-cut Passive RPLC RPLC UV-vis Sagirli et al. 2015
Phospholipids Food on-line heart-cut Passive HILIC RPLC MS Sun et al. 2015
Phosphatidylcholine isomers Food on-line heart-cut Passive HILIC RPLC MS Sun et al. 2014
Therapeutic antibodies Biopharma on-line comprehensive Passive RPLC RPLC MS, UV-vis Vanhoenacker et al. 2015
Wastewater effluent (toxicants) Environmental on-line comprehensive Passive RPLC RPLC MS, UV-vis Ouyang et al. 2015
Peptides (from milk) Food on-line comprehensive Passive RPLC RPLC UV-vis Sommella et al. 2015
TCM (Tripterygium wilfordii Hook.f) Natural medicines on-line comprehensive Passive RPLC RPLC MS Qu et al. 2015
TCM (triterpenoid saponins) Natural medicines on-line heart-cut Stop-flow HILIC RPLC MS Wang et al. 2015
TCM (Carthamus tinctorius L.) Natural medicines off-line comprehensive Manual HILIC RPLC MS Yang et al. 2015
TCM (Panax notoginseng saponins) Natural medicines on-line mult. heart-cut Passive RPLC RPLC UV-vis Yao et al. 2015
Dairy products (Proteins and additives) Food on-line heart-cut Stop-flow RPLC RPLC UV-vis Hou et al. 2015
Flavonoids and iridoid glycosides in Hedyotis diffusa Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Li et al. 2015
Antibody-drug conjugates (free species) Biopharma on-line heart-cut Passive SEC RPLC MS, UV-vis Li et al. 2015
Pharmaceuticals (naproxen and degradants) Pharmaceuticals on-line comprehensive Passive RPLC RPLC UV-vis Stoll et al. 2015
Glycated albumin (digest) Peptides on-line heart-cut SPAM Affinity RPLC MS Pepaj et al. 2015
Tryptic digests Peptides on-line comprehensive Passive RPLC RPLC UV-vis Sarrut et al. 2015
Wastewater effluent (pharmaceuticals and pesticides) Environmental on-line comprehensive Passive RPLC RPLC MS Leonhardt et al. 2015
Carboxilic acids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Stoll et al. 2015
TCM (bufadienolides in toad skin) Natural medicines off-line comprehensive Manual NPLC RPLC MS Zhang et al. 2015
TCM (antioxidants in Ginkgo biloba extract) Natural medicines on-line comprehensive Passive RPLC RPLC UV-vis Guo et al. 2015
TCM (Hypericum ascyron extract) Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Li et al. 2015
Red chili pepper (caretenoids) Food on-line comprehensive Passive NPLC RPLC MS, UV-vis Mondello et al. 2014
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC RPLC MS, UV-vis Venkatramani et al. 2014
Vancomycin in plasma Pharmaceuticals on-line heart-cut SPAM RPLC RPLC UV-vis Li et al. 2014
Anthocyanins in blue berries, red radish, cabbage and black beans Food off-line comprehensive Passive HILIC RPLC MS Willemse et al. 2014
White wine and TCM Food on-line comprehensive Passive MM RPLC UV-vis Li et al. 2014
Neurotransmitters Metabolites on-line heart-cut Passive RPLC RPLC MS, Other Holland et al. 2014
Tryptic digest (endogenous PSA) Peptides on-line heart-cut SPAM HILIC RPLC MS Simon et al. 2014
Phosphatidylcholine isomers in cell membranes Miscellaneous on-line heart-cut Passive HILIC RPLC MS Sun et al. 2014
poly(styrene)-co-poly(methyl methacrylate)latex Polymers on-line comprehensive Passive RPLC SEC UV-vis Schoenmakers et al. 2014
Synthetic polymers (polystyrene) Polymers on-line comprehensive Passive NPLC SEC UV-vis Jeong et al. 2014
Synthetic polymers (polysorbate) Polymers on-line heart-cut Passive MM RPLC UV-vis Li et al. 2014
Bio-oil (organic acids) Miscellaneous on-line comprehensive Passive RPLC RPLC MS Le Masle et al. 2014
Oligonucleotides Miscellaneous off-line comprehensive Manual IP-RPLC CE UV-vis Porebski 2014
Milk powder (carbohydrates) Food on-line heart-cut SPAM RPLC RPLC RID Ma et al. 2014
Sugar phosphates in yeast cells Metabolites on-line heart-cut Passive SAX RPLC MS Klavins et al. 2014
Polycyclic aromatic compounds Miscellaneous on-line comprehensive Passive RPLC RPLC UV-vis Græsbøll et al. 2014
Corn seed, Gingo Biloba and valerian root Natural medicines on-line heart-cut SPAM RPLC RPLC UV-vis Allen et al. 2014
Polycyclic aromatic hydrocarbons Miscellaneous on-line comprehensive Passive RPLC RPLC UV-vis Place et al. 2014
Synthetic polymers (poly(propylene) copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Cheruthazhekatt et al. 2014
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC RPLC UV-vis Shackman et al. 2014
Phenolic antioxidants Food on-line comprehensive Passive HILIC RPLC Other, UV-vis Kalili et al. 2014
TCM (Radix et Rhizoma Asari) Natural medicines on-line heart-cut SPAM Affinity RPLC MS Han et al. 2014
Sugarcane leaf (polyphenols) Food on-line comprehensive Passive RPLC RPLC MS Leme et al. 2014
TCM (P. lobata) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Qiao et al. 2014
Lipidomics (human plasma) Metabolites on-line heart-cut VEM NPLC RPLC MS Li et al. 2014
Milk powder (flavonoids) Food on-line heart-cut SPAM RPLC RPLC UV-vis Ma et al. 2014
Fatty alcohol ethoxylates Surfactants on-line heart-cut Passive RPLC RPLC UV-vis Escrig-Doménech et al. 2014
Brown algae (phlorotannins) Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2014
Synthetic polymers (ethylene/1‐octene copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Mekab et al. 2014
Lipidomics (human plasma) Metabolites on-line comprehensive Stop-flow HILIC RPLC MS Wang et al. 2013
Furanocoumarins Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Tran et al. 2013
Red wine Food on-line comprehensive Passive MM RPLC UV-vis Matos et al. 2013
Wastewater effluent (contaminants) Environmental on-line comprehensive Passive RPLC RPLC MS Haun et al. 2013
Apples (phenolic compounds) Food on-line comprehensive Passive HILIC RPLC MS, UV-vis Montero et al. 2013
Synthetic polymers (tacticity of Poly(Methyl Methacrylates)) Polymers on-line comprehensive Passive RPLC SEC ELSD Maiko et al. 2013
Phospholipids Metabolites on-line heart-cut Passive SAX RPLC MS Bang et al. 2013
Grape Seed Food on-line comprehensive Passive HILIC RPLC MS Kalili et al. 2013
Pharmaceuticals (enantiomeric excess) Pharmaceuticals on-line heart-cut Passive NPLC Chiral UV-vis Liu et al. 2013
Tryptic digest (BSA, lysozyme and myoglobine) Peptides on-line comprehensive Passive RPLC RPLC UV-vis D'Attoma et al. 2013
Lipidomics (porcine brain) Metabolites off-line heart-cut Manual HILIC RPLC MS Cífková et al. 2013
Synthetic polymers (cellulose acetates) Polymers off-line heart-cut Manual NPLC SEC ELSD Ghareeb et al. 2013
Tartary buckwheat Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Ren et al. 2013
Synthetic polymers (high-density polyethylene) Polymers on-line comprehensive Passive RPLC SEC ELSD Ginzburg et al. 2013
TCM (Hedyotis diffusa) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Li et al. 2013
Lipidomics (human plasma) Metabolites on-line heart-cut VEM NPLC RPLC MS Li et al. 2013
Pesticide residues Food on-line heart-cut SPAM HILIC RPLC MS Kittlaus et al. 2013
Synthetic polymers (RAFT polymerization) Polymers on-line comprehensive Passive LCCC SEC ELSD Keddie et al. 2013
TCM (Amide alkaloids in Piper longumL.) Natural medicines off-line comprehensive Passive NPLC RPLC MS Li et al. 2013
Cocoa (procyanidins) Food on-line comprehensive Passive HILIC RPLC FLD, UV-vis 10.1016/j.chroma.2013.03.009 2013
Synthetic polymers (polypropylene copolymers) Polymers on-line comprehensive Passive NA-RPLC SEC ELSD Cheruthazhekatt et al. 2013
Synthetic polymers (functionalized polyolefins) Polymers on-line comprehensive Passive NA-RPLC SEC ELSD Ginzburg et al. 2013
Pesticides Food on-line heart-cut SPAM HILIC RPLC MS Kittlaus et al. 2013
Phospholipids Metabolites on-line comprehensive Stop-flow HILIC RPLC MS Dugo et al. 2013
Apiaceous vegetables (furanocoumarins) Food on-line selective compr. Passive RPLC RPLC UV-vis Larson et al. 2013
Tryptic digest (porcine circovirus type 2) Peptides off-line heart-cut Manual SCX RPLC MS Liu et al. 2013
Peanut oil (triacylglycerols) Food off-line comprehensive Manual NA-RPLC AgLC MS Hu et al. 2013
Tryptic digest (antiviral factors) Peptides off-line heart-cut Manual SCX RPLC MS Tong et al. 2013
Pharmaceutical drugs Pharmaceuticals on-line heart-cut Passive RPLC Chiral UV-vis Lee et al. 2013
Fatty alcohol derivatives Surfactants on-line comprehensive Passive HILIC RPLC MS Elsner et al. 2012
Phenolic compounds Metabolites on-line comprehensive Passive HILIC RPLC UV-vis Jandera et al. 2012
Synthetic polymers (protonated and deuterated polystyrene) Polymers on-line comprehensive Passive LCCC SEC ELSD Sinha et al. 2012
Tryptic digest (Gly m 4 Protein) Peptides on-line heart-cut SPAM SAX RPLC MS, UV-vis Julka et al. 2012
Pharmaceutical drugs Pharmaceuticals off-line comprehensive Manual RPLC HILIC CAD, MS Schiesel 2012
Synthetic polymers (poly(ethylene oxide)) Polymers on-line comprehensive Passive RPLC SEC NMR Hiller et al. 2012
Histone post-translational modifications (Intact) Proteins off-line heart-cut Manual MM RPLC MS Tian et al. 2012
Tryptic digest (scorpion Buthus martensi Karsch venom) Peptides off-line heart-cut Manual RPLC HILIC MS Xu et al. 2012
Synthetic polymers (Poly(styrene‑b‑isoprene) Miktoarm StarCopolymers) Polymers on-line comprehensive Manual RPLC SEC ELSD, UV-vis Ljubič et al. 2012
Synthetic polymers (PMMA and polyurethanes) Polymers on-line comprehensive Passive RPLC SEC ELSD, UV-vis Uliyanchenko et al. 2012
Tryptic digest (host cell protein impurities) Peptides off-line heart-cut Manual RPLC RPLC MS Schenauer et al. 2012
Synthetic oligonucleotides Pharmaceuticals on-line comprehensive Passive HILIC RPLC MS Li et al. 2012
Maize seeds Food on-line comprehensive Passive RPLC RPLC UV-vis Allen et al. 2012
TCM (Anemarrhena asphodeloides, steroid glycoside) Natural medicines on-line comprehensive Passive RPLC RPLC MS Liu et al. 2012
Tryptic digest (Methylocellasilvestris) Peptides on-line heart-cut Passive RPLC RPLC MS Patel et al. 2012
TCM (Qingkailing) Natural medicines on-line selective compr. Passive RPLC RPLC MS, UV-vis Ma et al. 2012
Natural organic matter Environmental on-line comprehensive Passive HILIC SEC ELSD, FLD, UV-vis Duarte et al. 2012
Natural organic matter Environmental on-line comprehensive Passive RPLC SEC ELSD, FLD, UV-vis Duarte et al. 2012
Tryptic digest (Bacillus thuringiensis) Peptides on-line heart-cut SPAM SCX RPLC MS Huang et al. 2012
Natural antioxidants Metabolites off-line heart-cut Manual RPLC MEKC UV-vis Česla et al. 2012
TCM (Radix Angelica sinensis) Natural medicines on-line comprehensive Passive RPLC RPLC MS Dück et al. 2012
D‐/L‐phenylalanine Pharmaceuticals on-line heart-cut Passive RPLC Chiral UV-vis Venkatramani et al. 2012
D‐/L‐phenylalanine Pharmaceuticals on-line comprehensive Passive RPLC Chiral UV-vis Venkatramani et al. 2012
Organic acids (aromatics and flavanoids) Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Hájek et al. 2012
Shotgun proteomics Peptides on-line heart-cut SPAM HILIC RPLC MS Zhao et al. 2012
Rooibos tea (phenolics) Food on-line comprehensive Passive HILIC RPLC UV-vis Beelders et al. 2012
TCM (Stevia Rebaudiana) Natural medicines off-line comprehensive Manual RPLC HILIC MS Fu et al. 2012
Synthetic polymers (polystyrene-polyethylene oxide block copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Malik et al. 2012
TCM (Panax notoginseng saponins) Natural medicines off-line comprehensive Manual HILIC RPLC MS, UV-vis Xing et al. 2012
Peanut oil and mouse tissue (triacylglycerides) Lipids on-line heart-cut Passive AgLC RPLC MS Yang et al. 2012
Synthetic polymers (Branched Polymers) Polymers on-line comprehensive Passive RP-TGIC SEC LS, RI, VI Ahn et al. 2012
Synthetic polymers (Poly(styrene-block-t-butyl methacrylate) Copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Ljubič et al. 2012
Synthetic polymers (Poly(styrene-block-t-butyl methacrylate) Copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Ljubič et al. 2012
Tryptic digest (neutrophils) Peptides off-line heart-cut Manual SCX RPLC MS Trusch et al. 2012
Synthetic polymers (PDMS-PS block copolymers) Polymers off-line comprehensive Passive LCCC SEC ELSD, UV-vis Malik et al. 2012
Endocrine disrupting compounds in water Environmental on-line heart-cut Passive RPLC RPLC MS David Matějíček 2012
Corn seed Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Paek et al. 2012
Tryptic digest (rat brain) Peptides off-line heart-cut Manual RPLC WCX MS Cai et al. 2012
Maize seed extract Food on-line comprehensive Passive RPLC RPLC UV-vis Zhang et al. 2012
Wastewater effluent (cocaince) Environmental on-line selective compr. Passive RPLC RPLC MS Groskreutz et al. 2012
Opiates Pharmaceuticals on-line selective compr. Passive RPLC RPLC UV-vis Groskreutz et al. 2012
Taxanes Pharmaceuticals on-line heart-cut Passive HILIC RPLC MS Rezadoost et al. 2012
Licorice (liquiritin) Food off-line comprehensive Passive RPLC RPLC UV-vis Cong et al. 2012
Synthetic polymers (polypropylene Copolymers) Polymers on-line comprehensive Passive RPLC SEC ELSD Cheruthazhekatt et al. 2012
Organic acids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Duarte et al. 2012
TCM (Scutellaria barbata D. Don) Natural medicines off-line comprehensive Manual HILIC RPLC MS, UV-vis Liang et al. 2012
TCM (Scutellaria barbata D. Don) Natural medicines off-line comprehensive Passive HILIC HILIC MS, UV-vis Liang et al. 2012
Tryptic digest (phosphorylated peptides) Peptides off-line heart-cut Manual RPLC RPLC MS Stephanowitz et al. 2012
Green and black tea (Camellia sinensis, phenolics) Food off-line comprehensive Manual SEC RPLC ELSD, UV-vis Scoparo et al. 2012
Tryptic digest (serum) Peptides off-line heart-cut Manual SCX RPLC MS Zhang et al. 2012
TCM (flavanoids) Natural medicines off-line heart-cut Manual RPLC RPLC MS Zeng et al. 2012
Monoclonal antibodies Biopharma on-line heart-cut SPAM RPLC RPLC MS Doneanu 2012
Alkylphenol polyethoxylates Surfactants on-line comprehensive Passive HILIC RPLC MS Wu et al. 2011
Monoclonal antibodies Biopharma on-line heart-cut SPAM MM RPLC MS, UV-vis Alvarez et al. 2011
Maize extract Food on-line comprehensive Passive RPLC RPLC UV-vis Filgueira et al. 2011
Synthetic polymers (poly(2-ethyl-2-oxazoline) copolymers) Polymers on-line comprehensive Passive LCCC SEC Baumgaertel et al. 2011
TCM Natural medicines off-line heart-cut SPAM RPLC HILIC UV-vis Cao et al. 2011
Synthetic polymers (poly(ethylene-co-propylene)) Polymers on-line comprehensive Passive RPLC SEC IR, LS, RI Lee et al. 2011
Synthetic polymers (polystyrene) Polymers off-line comprehensive Manual SEC HDC UV-vis Uliyanchenko et al. 2011
Maize extract Food on-line comprehensive Passive RPLC RPLC UV-vis Gu et al. 2011
Hydroxypropylmethylcellulose (HPMC) Polymers on-line comprehensive Passive RPLC SEC CAD Greuderer et al. 2011
Lipidomics (egg, soya, porcine brain) Metabolites off-line heart-cut Manual HILIC NA-RPLC MS Lísa et al. 2011
Myoglobin, serum albumin, pepstatin, proteinase inhibitor (Intact) Proteins on-line heart-cut SPAM SCX RPLC MS, UV-vis Julka et al. 2011
River water (pollutants in Monjolinho River) Environmental on-line heart-cut Passive Affinity Chiral MS Barreiro et al. 2011
Tryptic digest (Trypsin, bovine serum, ovalbumin, lysozyme, hemoglobin) Peptides on-line heart-cut Passive WAX RPLC UV-vis Li et al. 2011
Estrogens in sediments Environmental on-line heart-cut Passive RPLC RPLC MS DavidMatějíček 2011
Synthetic polymers (polyolefins) Polymers on-line comprehensive Passive RPLC SEC ELSD Ginzburg et al. 2011
Borago officinalis oil (triacylglycerols) Lipids on-line comprehensive Passive AgLC NA-RPLC ELSD Mondello et al. 2011
Flavones in Citrus juices Food on-line comprehensive Passive RPLC RPLC UV-vis Russo et al. 2011
Peptides Peptides on-line heart-cut Passive RPLC CE MS Chambers et al. 2011
Metabolites (Saccharomyces cerevisae) Metabolites off-line comprehensive Manual SCX HILIC MS Fairchild et al. 2010
Non-ionic surfactants (Polysorbates, Tween) Surfactants on-line comprehensive Passive LCCC HILIC ELSD Abrar et al. 2010
Block copolymers Polymers on-line heart-cut Passive LCD SEC ELSD Berek et al. 2010
Phospholipids (plasma) Lipids on-line heart-cut Manual WAX RPLC MS Sato et al. 2010
Synthetic polymers (2-ethylhexyl acrylate and methyl acrylate RAFT) Polymers on-line comprehensive Passive SEC LCCC ELSD Raust et al. 2010
Antibody-drug conjugates Biopharmaceuticals on-line heart-cut Passive Affinity RPLC MS Murphy et al. 2010
Synthetic polymers (thylene-vinylacetate copolymers) Polymers on-line comprehensive Passive NPLC SEC ELSD Ginzburg et al. 2010
Low-molar-mass organic acids Food on-line comprehensive Passive SAX RPLC UV-vis Brudin et al. 2010
espresso coffees (ristretto, decaffeinatto, volluto) Food on-line comprehensive Passive RPLC RPLC Other, UV-vis Mnatsakanyan et al. 2010
Lipidomics (rat serum) Metabolites on-line heart-cut VEM NPLC RPLC MS Nie et al. 2010
Anti-PEG Antibody digest Peptides on-line heart-cut Passive SCX RPLC MS Xu et al. 2010
Coal tar Miscellaneous on-line heart-cut VEM NPLC RPLC UV-vis Ding et al. 2010
arctiin in fruit (Arctium lappa L.) Food on-line heart-cut Passive CCC RPLC UV-vis Guo et al. 2010
omeprazole in waste and estuarine water Environmental on-line heart-cut Passive Affinity Chiral MS Barreiro et al. 2010
TCM (Herba Hedyotis Diffusae) Natural medicines off-line comprehensive Manual RPLC HILIC UV-vis Feng et al. 2010
TCM (platycosides in Platycodi Radix) Natural medicines on-line comprehensive Passive RPLC RPLC MS Jeong et al. 2010
Antibody tryptic digests Peptides on-line heart-cut Passive Affinity RPLC MS, UV-vis Cho et al. 2010
Phenolic acids and flavones Food on-line comprehensive Passive RPLC RPLC UV-vis Jandera et al. 2010
Tryptic digest (pertussis toxoid) Peptides off-line heart-cut Manual RPLC RPLC MS Tummala et al. 2010
Synthetic polymers (fatty alcohol ethoxylates) Polymers on-line comprehensive Passive RPLC NPLC ELSD Raust et al. 2010
Chiral enantiomers (amino acids in irradiated foodstuffs) Food on-line heart-cut Passive RPLC Chiral Guillén-Casla et al. 2010
Human plasma protein Peptides off-line heart-cut Manual SCX RPLC MS Ahrends et al. 2010
TCM (Corydalis yanhusuo, antinociceptive components) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Wang et al. 2010
Drug metabolites in urine Metabolites on-line heart-cut SPAM RPLC RPLC MS Jayamanne et al. 2010
Synthetic polymers (polyoxyalkylene block copolymers) Polymers off-line heart-cut Manual LCCC SEC MS Malik et al. 2010
Synthetic polymers (Polysorbates) Polymers on-line comprehensive Passive NPLC LCCC ELSD Trathnigg et al. 2010
Cr-enriched yeast Miscellaneous off-line heart-cut Manual SEC RPLC MS Kaewkhomdee et al. 2010
TCM (Rheum Palmatum L) Natural medicines off-line comprehensive Manual RPLC RPLC UV-vis Xue et al. 2009
Whey protein hydrolysate Peptides on-line comprehensive Passive RPLC RPLC UV-vis Bedani et al. 2009
Polyphenols in red wines Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Mondello et al. 2009
Polyphenolic antioxidants in red wine Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Dugo et al. 2008
Tryptic digest (transferrin, BSA, alcohol dehydrogenase, lysozyme, cytochrome c, beta-casein, mAb) Peptides on-line comprehensive Passive SCX RPLC MS, UV-vis Eeltink et al. 2009
TCM (Zhengtian pills) Natural medicines on-line comprehensive Stop-flow NPLC RPLC UV-vis Wei et al. 2009
Polyphenols in mate extracts Food on-line comprehensive Passive RPLC RPLC MS, UV-vis Dugo et al. 2009
Tryptic digest (Human Glioblastoma Multiforme Tissue) Peptides off-line heart-cut Manual SCX IP-RPLC MS Melchior 2009
Recombinant antibody-related drugs (rAbs) Peptides on-line heart-cut Passive Affinity RPLC UV-vis Zhang et al. 2009
Synthetic polymers (Caprolactone) Polymers off-line comprehensive Manual LCCC RPLC ELSD Ahmed et al. 2009
Taxanes in Taxus baccata L. Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Ghassempour et al. 2009
Epoxy resins Polymers on-line comprehensive Passive SEC LCCC MS, UV-vis Julka et al. 2009
Complex polymers (PS-b-PI-b-PS triblock copolymer, mikto arm block copolymer) Polymers on-line comprehensive Passive SEC NPLC UV-vis Im et al. 2009
Complex polymers (PS-b-PI-b-PS triblock copolymer, mikto arm block copolymer) Polymers on-line comprehensive Passive RP-TGIC SEC UV-vis Im et al. 2009
Cytochrome c, myoglobin, ribonuclease A, lysozyme, alpha-amylase, alpha-chymotrypsin, insulin (Intact) Proteins on-line mult. heart-cut Passive HIC WCX MS Geng et al. 2009
Antioxidants Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Česla et al. 2009
Active pharmaceutical ingredients (API) and degradants Pharmaceuticals on-line comprehensive Passive RPLC RPLC UV-vis Alexander et al. 2009
TCM (Fructus aurantii, flavones) Natural medicines off-line heart-cut Manual RPLC RPLC MS, UV-vis Zhou et al. 2009
Tryptic digest (BSA, cytochrome c, beta-casein, myoglobin and lysozyme) Peptides off-line heart-cut Manual SCX RPLC MS Wang et al. 2009
Flavonol glycosides from leaves of Maytenus ilicifolia Natural medicines off-line comprehensive Manual SEC RPLC MS de Souza et al. 2009
TCM (Carthamus tinctorius Linn.) Natural medicines off-line heart-cut Manual RPLC HILIC UV-vis Liu et al. 2008
Manganese binding to biomolecules in pine nuts Food off-line heart-cut Manual SEC RPLC Arias-Borrego et al. 2008
Synthetic polymers (Polystyrene‐block‐Polyisoprene Diblock Copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Mass et al. 2008
Synthetic polymers ((meth)acrylate-based copolymers) Polymers on-line comprehensive Passive NA-RPLC SEC ELSD Raust et al. 2008
Sulphonated lignins Polymers on-line comprehensive Passive IP-RPLC SEC Brudin et al. 2008
Phenolic compounds in beverages Food on-line comprehensive Passive RPLC RPLC Kivilompolo et al. 2008
Synthetic polymers (branched polymers) Polymers on-line comprehensive Passive MTF SEC UV-vis Edam et al. 2008
Protein extracts (Intact) Protein off-line heart-cut Manual IEF RPLC UV-vis Suberbielle et al. 2008
2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in Class III caramel colours Food on-line heart-cut Passive RPLC RPLC UV-vis Moretton et al. 2008
TCM (Lobelia chinensis Lour.) Natural medicines off-line heart-cut Manual RPLC RPLC MS, UV-vis Zhou et al. 2008
TCM (Radix salviae miltiorrhiza bage) Natural medicines on-line comprehensive VEM NPLC RPLC MS Tian et al. 2008
Carotenoids in Red Orange Oil Food on-line comprehensive Passive NPLC RPLC MS, UV-vis Dugo et al. 2008
Alprazolam Pharmaceuticals off-line comprehensive Manual RPLC RPLC UV-vis Huidobro et al. 2008
Tryptic digest (cytochrome C, lysozyme C, alcohol dehydrogenase, BSA, serotransferrin) Peptides on-line heart-cut SPAM SCX RPLC Hesse et al. 2008
Phenolic acids Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Jandera et al. 2008
Antioxidant phenols in wine and juice Food on-line comprehensive Passive RPLC RPLC UV-vis Kivilompolo et al. 2008
Peptides in milk hydrolysates Food off-line heart-cut Manual RPLC HILIC MS Platerink et al. 2008
Pharmaceuticals in urine Pharmaceuticals on-line comprehensive Passive RPLC RPLC MS, UV-vis Eggink et al. 2008
Tryptic digest (myoglobin and BSA) Peptides off-line comprehensive Manual SCX RPLC UV-vis Marchetti et al. 2008
TCM (Swertia franchetiana Smith) Natural medicines off-line heart-cut Manual RPLC RPLC MS Liu et al. 2008
Polyphenols Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Jandera et al. 2008
TCM (saponins from Quillaja saponaria) Natural medicines on-line comprehensive Passive HILIC HILIC MS Wang et al. 2008
Lemon oil extract Food on-line comprehensive Passive NPLC RPLC François et al. 2008
Triacylglycerols in corn oil Food on-line comprehensive Passive AgLC RPLC ELSD, MS, UV-vis van der Klift et al. 2008
Active components in licorice Food on-line heart-cut Passive RPLC RPLC UV-vis Cong et al. 2008
Taxus baccata L. Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Ghassempour et al. 2008
Corn seed powder extract Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Stoll et al. 2008
TCM (Magnolia biondii, lignans) Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Zhao et al. 2007
High intensity sweeteners in plants Food on-line comprehensive Passive RPLC RPLC MS Pól et al. 2007
High intensity sweeteners in plants Food on-line comprehensive Passive SCX RPLC MS Pól et al. 2007
Polyphenols in beverages Food on-line comprehensive SPAM RPLC RPLC UV-vis Cacciola et al. 2007
Tryptic digest (HepG2 proteome) Peptides on-line heart-cut Passive SCX RPLC MS Yamashita et al. 2007
TCM (Flos Lonicera) Natural medicines on-line comprehensive Passive SAX RPLC MS, UV-vis Chen et al. 2007
Tryptic digest (cytochrome c) Peptides on-line heart-cut Passive SCX RPLC MS Liu et al. 2007
Apo A‐I in human plasma (Intact) Proteins on-line heart-cut SPAM RPLC SAX UV-vis Pepaj et al. 2007
Antioxidant phenolic acids in Lamiaceae herbs Food on-line comprehensive Passive RPLC RPLC MS Kivilompolo et al. 2007
excreta (feces or urine) extracts from rats or mice Metabolites off-line heart-cut Manual RPLC RPLC MS, UV-vis Kiffe et al. 2007
Tryptic digest (cell lysate) Peptides off-line heart-cut Manual HILIC RPLC Boersema et al. 2007
Metabolites in urine Metabolites off-line heart-cut Manual RPLC RPLC MS Trunzer et al. 2007
Synthetic polymers (PS-b-PI diblock copolymer) Polymers on-line comprehensive SPAM NP-TGIC NA-RPLC UV-vis Im et al. 2007
TCM (Angelica dahurica) Natural medicines on-line heart-cut VEM NPLC RPLC UV-vis Tian et al. 2006
BioZate3 Peptides on-line comprehensive Stop-flow SEC RPLC MS, UV-vis Bedani et al. 2006
Phenolic antioxidants Food on-line comprehensive SPAM RPLC RPLC UV-vis Cacciola et al. 2006
Tryptic digest (proteins extracted from normal human liver tissue) Peptides on-line heart-cut Passive SCX RPLC MS Gu et al. 2006
Acidic compounds in atmospheric aerosols Environmental on-line comprehensive Passive SCX RPLC MS Pól et al. 2006
Synthetic polymers (poly(ethylene glycol)-poly(vinyl acetate) graft copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Knecht et al. 2006
Poly(bisphenol A)carbonate and polymers Polymers on-line comprehensive Passive LCCC SEC IR Coulier et al. 2006
Synthetic polymers (Linear and 3‐Arm Star Block Copolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Gao et al. 2006
TCM (Adinandra nitida) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Zhang et al. 2006
TCM (Qingkailing) Natural medicines off-line comprehensive Manual SEC RPLC UV-vis Ma et al. 2006
Biomarkers in rat plasma Peptides off-line heart-cut Passive IEF RPLC MS Linke et al. 2006
Indoles in wild-type maize seed extracts Metabolomics on-line comprehensive Passive SCX RPLC UV-vis Porter et al. 2006
Tryptic digest (bovine serum albumin, BSA) Peptides on-line comprehensive Passive SCX RPLC UV-vis Stoll et al. 2005
Synthetic polymers (thylene oxide–propylene oxide (co)oligomers) Polymers on-line comprehensive Passive RPLC HILIC ELSD Jandera et al. 2006
Selenium species in aqueous extracts of alfalfa sprouts Metabolites off-line comprehensive Passive SEC IP-RPLC ICP-MS Gergely et al. 2006
Triacylglycerols Lipids on-line comprehensive Passive AgLC NA-RPLC MS Dugo et al. 2006
Triacylglycerols in milk Food on-line comprehensive Passive AgLC NA-RPLC MS Dugo et al. 2006
Tryptic digest (plant tissues) Peptides on-line comprehensive Passive HPCF RPLC MS Pirondini et al. 2006
Synthetic polymers (poly(bisphenol A)carbonate, degraded) Polymers on-line comprehensive Passive LCCC SEC IR, MS Coulier et al. 2006
Polyphenols Food on-line comprehensive Passive NPLC RPLC UV-vis Dugo et al. 2006
Synthetic polymers (styrene-methylacrylate (SMA) copolymers) Polymers on-line comprehensive Passive RPLC SEC IR, UV-vis Kok et al. 2005
Triacylglycerol in food Lipids on-line comprehensive Passive AgLC NA-RPLC MS, UV-vis Mondello et al. 2005
Tryptic digest (C. elegans) Peptides on-line heart-cut SPAM SCX RPLC MS Tschäppät et al. 2005
Synthetic polymers (poly(bisphenol A)carbonate) Polymers on-line comprehensive Passive NPLC SEC UV-vis Coulier et al. 2005
Synthetic polymers (poly(bisphenol A)carbonate) Polymers on-line comprehensive Passive LCCC SEC UV-vis Coulier et al. 2005
Organic acids Metabolites on-line comprehensive Passive RPLC MM UV-vis Venkatramani et al. 2005
Tryptic digest (D20) Peptides on-line heart-cut SPAM RPLC SCX MS Wang et al. 2005
Synthetic polymers (poly(methyl methacrylate)) Polymers on-line comprehensive Passive LCCC SEC ELSD, UV-vis Jiang et al. 2005
Synthetic polymers (n-butyloligostyrenes) Polymers on-line heart-cut Passive RPLC RPLC UV-vis Gray et al. 2005
Tryptic digest (26S and 20S proteasome) Peptides off-line heart-cut Manual SCX RPLC MS Fujii et al. 2004
Tryptic digest (PUMA-Induced Apoptosis samples) Peptides on-line heart-cut Passive SCX RPLC MS Gu et al. 2004
Tryptic digest (saliva proteome) Peptides off-line heart-cut Manual SCX RPLC MS Wilmarth et al. 2004
Tryptic digest (human serum proteins) Peptides off-line heart-cut Manual RPLC CE MS Janini et al. 2004
TCM (Rhizoma chuanxiong) Natural medicines on-line comprehensive Passive RPLC RPLC MS, UV-vis Chen et al. 2004
Oligoalanine peptide stereoisomers Peptides on-line heart-cut Passive RPLC Chiral MS Czerwenka et al. 2004
Clerodendrum floribundum Natural medicines on-line heart-cut Passive RPLC RPLC UV-vis Wong et al. 2004
Synthetic polymers (PLA/PDMS graft terpolymers) Polymers on-line comprehensive Passive LCCC SEC ELSD Lutz et al. 2004
Tryptic digests (A431) Peptides on-line heart-cut Passive SCX RPLC MS Chelius et al. 2003
Synthetic polymers (poly(methyl methacrylate)) Polymers on-line comprehensive Passive RPLC SEC ELSD Siewing et al. 2003
Tryptic digest (bovine proteins) Peptides on-line heart-cut Passive SCX RPLC MS Nägele et al. 2003
Aromatic and non-aromatic amines Metabolites on-line comprehensive Passive RPLC RPLC UV-vis Venkatramani et al. 2003
Synthetic polyemers (polystyrene, PMMA) Polymers on-line comprehensive Passive NA-RPLC SEC UV-vis van der Horst et al. 2003
Triacylglycerides in edible oils and fats Lipids off-line comprehensive Manual AgLC GC FID Janssen et al. 2003
Triacylglycerides in edible oils and fats Lipids off-line comprehensive Manual NPLC GC FID Janssen et al. 2003
Tryptic digest (Caenorhabditis elegans) Peptides on-line heart-cut SPAM SCX RPLC MS Mawuenyega et al. 2003
Synthetic polymers (styrene-butadiene and butyl rubber) Polymers on-line comprehensive Passive NA-RPLC SEC ELSD Heinz et al. 2003
Tryptic digest (protein mixtures) Peptides on-line heart-cut SPAM SCX RPLC MS Qiu et al. 2002
Selenium-containing biomolecules from yeast extracts Peptides off-line heart-cut Manual SEC RPLC ICP-MS Lindemann et al. 2002
Synthetic polymers (polystyrene) Polymers on-line heart-cut SPAM RPLC RPLC UV-vis Sweeney and Shalliker 2002
Fatty acid polyglycol ethers Surfactants on-line heart-cut SPAM LCCC RPLC ELSD, RI Trathnigg et al. 2002
Cell extracts (proteins, metabolites) (Intact) Proteins off-line comprehensive Manual RPLC CE UV-vis He et al. 2002
Biological matrices (incl pecan nut, straw, mouse plasma) Miscellaneous on-line heart-cut Passive RPLC RPLC MS Pascoe et al. 2001
Synthetic polymers (EPDM polymers with grafted methyl methacrylate) Polymers on-line comprehensive Passive LCCC NA-RPLC ELSD, UV-vis Siewing et al. 2001
Proteins from human breast cancer whole cell lysates (Intact) Proteins off-line heart-cut Manual HPCF RPLC MS Chong et al. 2001
Selenium speciation in selenized yeast extracts (Intact) Proteins off-line heart-cut Manual SEC RPLC ICP-MS McSheehy et al. 2001
Proteins (mixture) (Intact) Proteins on-line comprehensive Passive SCX RPLC MS, UV-vis Wagner et al. 2000
JP-TS jet fuel Energy carriers on-line comprehensive Thermal GC GC FID Fraga et al. 2000
t,t-muconic acid in human urine Metabolites on-line heart-cut SPAM RPLC RPLC UV-vis Serena et al. 2000
Fatty alcohol ethoxylates Polymers on-line heart-cut Passive LCC SEC ELSD Trathnigg et al. 1999
Alcohol Ethoxylates Surfactants on-line comprehensive Passive NPLC RPLC ELSD Murphy et al. 1998
Tryptic digest (BSA) Peptides on-line heart-cut Passive SEC RPLC MS Opiteck et al. 1998
Tryptic digests (ovalbumin and serum albumin) Peptides on-line comprehensive Passive SEC RPLC MS Opiteck et al. 1997
Escherichia coli cell lysate Proteins on-line comprehensive Passive SCX RPLC MS, UV-vis Opiteck et al. 1997
fluorescein 5-isothiocyanate (FITC)-labeled phenylalanine and glutamic acid Metabolites on-line heart-cut Cross-flow RPLC CE LIF Hooker et al. 1997
Polyesters, polyethers and macromers Polymers off-line heart-cut Manual LCCC SEC MS Krüger et al. 1996
Ethoxylated fatty alcohols Surfactants off-line comprehensive Manual LCCC SEC RI Trathnigg et al. 1995
Biological amines Metabolites on-line heart-cut Passive SAX RPLC UV-vis Holland et al. 1995
Ethoxylated fatty alcohols Surfactants off-line comprehensive Manual LCCC SEC RI Trathnigg et al. 1994
Peptide from rat brain tissue Peptides off-line heart-cut Manual SAX RPLC UV-vis Lundell et al. 1992
Plant extracts Metabolites on-line heart-cut Passive SEC RPLC UV-vis Erni and Frei 1978
Additives in cellulose acetate polymer Miscellaneous on-line heart-cut Passive SEC RPLC UV-vis Th. R. Floyd 1988
Protein mixtures (Intact) Proteins on-line comprehensive Passive SCX SEC UV-vis Bushey and Jorgenson 1990
Monoclonal antibodies Biopharma on-line comprehensive Passive SEC SEC MS Ehkirch et al. 2018
TCM (Flos Lonicerae Japonicae) Natural medicines off-line comprehensive Manual HILIC RPLC MS, UV-vis Zhao et al. 2019
Josamycin (degradation products and impurities) Pharmaceuticals on-line mult. heart-cut Passive RPLC RPLC MS Liu et al. 2019
Enoxaparins Pharmaceuticals on-line mult. heart-cut Passive SEC RPLC MS Ouyang et al. 2019
Acrylate-modified hyaluronic acid Polymers on-line comprehensive Passive RPLC SEC ELSD Viktor et al. 2019
Poly-1-octene (tacticity) Polymers on-line comprehensive Passive RPLC SEC ELSD, RI, NMR Rode et al. 2019
Metal-based anticancer drugs Pharmaceuticals on-line heart-cut Passive SEC RPLC ICP-MS Galvez et al. 2019
TCM (Arenaria kansuensis) Natural medicines off-line heart-cut Passive RPLC RPLC UV-vis Cui et al. 2019
Gluconic acid in honey samples Food on-line heart-cut Passive SEC RPLC MS Suto et al. 2019
tartary buckwheat (Fagopyrum tataricum) seeds Peptides off-line heart-cut Manual RPLC RPLC MS Wang et al. 2019
Lignocellulosic biomass products Miscellaneous off-line comprehensive Manual CPC RPLC MS Dubuis et al. 2019
Polyphenolic fraction of Pistacia vera L. kernel extracts Food on-line comprehensive Passive RPLC RPLC MS Arena et al. 2019
Monoterpene indole alkaloids in biological matrices Food on-line heart-cut Passive SCX RPLC MS Liu et al. 2019
Branching analysis of star-shaped polystyrenes Polymers on-line comprehensive Passive TGIC SEC LS, RI, VI Murima et al. 2019
Pesticide multi-screening Environmental on-line mult. heart-cut Passive HILIC RPLC MS Muehlwald et al. 2019
Drug metabolites Pharmaceuticals on-line mult. heart-cut SPAM RPLC RPLC MS, UV-vis Koppen et al. 2019
Pesticides Environmental on-line mult. heart-cut Passive RPLC RPLC UV-vis Pursch et al. 2017
Cytochrome C, carbonic anhydrase, beta-casein, beta-lactoglobulin, alpha-lactalbumin Proteins on-line comprehensive Passive RPLC RPLC MS Baghdady et al. 2019
Asn, Ser, Ala and Pro Enantiomers Pharmaceuticals on-line 3DLC Passive RPLC WAX FLD Furusho et al. 2019
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